{"id":"W4249035566","doi":"10.21203/rs.3.rs-384297/v1","title":"A Novel Blood-Based Assay for Treatment Monitoring of Tuberculosis","year":2021,"lang":"en","type":"preprint","venue":"Research Square","topic":"Tuberculosis Research and Epidemiology","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institutes of Health; Ministerie van Buitenlandse Zaken; Department of Foreign Affairs and Trade, Australian Government; U.S. Department of Defense; Australian Government; National Institute of Allergy and Infectious Diseases; Bill and Melinda Gates Foundation; Bundesministerium für Bildung, Wissenschaft, Forschung und Technologie; Universidad Peruana Cayetano Heredia; Dr. Ralph and Marian Falk Medical Research Trust","keywords":"GeneXpert MTB/RIF; Medicine; Tuberculosis; Internal medicine; Gene signature; Tb treatment; Sputum; Gene; Gene expression; Pathology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001253413,0.0004391657,0.0005974851,0.001075195,0.0001424509,0.0006817845,0.0003519789,0.0007618212,0.001631237],"category_scores_gemma":[0.00207208,0.0001507846,0.0002887763,0.0007599012,0.0002504118,0.0002396834,0.0002564608,0.0005592595,0.0007000397],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003246809,"about_ca_system_score_gemma":0.0003211376,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005378143,"about_ca_topic_score_gemma":0.0006537262,"domain_scores_codex":[0.9980435,0.0007075482,0.00009227118,0.0003535834,0.000677824,0.0001251517],"domain_scores_gemma":[0.9990323,0.000332148,0.0002363402,0.00009289154,0.0002150905,0.00009132989],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002728859,0.0004925731,0.2764494,0.0003296639,0.0001551163,0.000171963,0.0001736165,0.0008990009,0.5985635,0.0003775839,0.002688582,0.1169701],"study_design_scores_gemma":[0.0002316652,0.004717448,0.5718439,0.00009643888,0.0002396138,0.002662461,0.0002263954,0.01778675,0.3899612,0.0007869727,0.0113618,0.00008540875],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9033511,0.006988262,0.07520089,0.0006191708,0.0004389005,0.0004669303,0.00676628,0.0014521,0.004716276],"genre_scores_gemma":[0.9451212,0.0006279513,0.04806926,0.0005362181,0.0001659938,0.0002563826,0.002199325,0.0000424801,0.002981303],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001631237,"threshold_uncertainty_score":0.006628752,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1554355068391152,"score_gpt":0.4606394630467094,"score_spread":0.3052039562075942,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}