{"id":"W4249071688","doi":"10.1210/me.14.3.429","title":"Synergy of Activin and Ciliary Neurotrophic Factor Signaling Pathways in the Induction of Vasoactive Intestinal Peptide Gene Expression","year":2000,"lang":"en","type":"article","venue":"Molecular Endocrinology","topic":"TGF-β signaling in diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; Jarislowsky Foundation; Massachusetts General Hospital","keywords":"Activin type 2 receptors; ACVR2B; Biology; Cell biology; Signal transduction; Activin receptor; Smad2 Protein; Internalization; Receptor; TGF beta signaling pathway; R-SMAD; Transforming growth factor beta; Endoglin; Transforming growth factor; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006403809,0.0001682029,0.0002028934,0.00009179895,0.00003744051,0.000005862588,0.0002247178,0.00009927036,0.00003464703],"category_scores_gemma":[0.0001004297,0.0001432548,0.00007299886,0.000103915,0.0001887337,0.000006770143,0.00008621126,0.0001647157,0.000001029713],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009136481,"about_ca_system_score_gemma":0.00006006917,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004591668,"about_ca_topic_score_gemma":0.000004998692,"domain_scores_codex":[0.9986609,0.0003203405,0.0002825217,0.000348361,0.0001416019,0.0002462975],"domain_scores_gemma":[0.9993923,0.00005426263,0.0001281716,0.0003330528,0.00005416413,0.00003803162],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001970451,0.0001372507,0.002036917,0.0000256424,0.00003633269,0.00005666975,0.0001541678,0.0008625492,0.9925674,0.00003649251,0.000005886992,0.003883598],"study_design_scores_gemma":[0.0004367403,0.0003548879,0.01394166,0.00003435167,0.00002281488,0.000117301,0.0001043724,0.00002529853,0.9845859,0.0001212082,0.0001352804,0.000120199],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980404,0.0008336757,0.0007449748,0.00003098359,0.00003312847,0.0001651266,0.00001706163,0.000008541931,0.0001261166],"genre_scores_gemma":[0.9990277,0.00008000633,0.0006901012,0.00006535392,0.00003871517,0.00003271034,0.00003509951,0.00001926901,0.00001108548],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01190474,"threshold_uncertainty_score":0.5841761,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0146401904898464,"score_gpt":0.2340738592074397,"score_spread":0.2194336687175933,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}