{"id":"W4249216413","doi":"10.2196/30737","title":"Novel Kappa-Opioid Receptor Agonist for the Treatment of Cholestatic Pruritus: Systematic Review","year":2022,"lang":"en","type":"article","venue":"JMIR Dermatology","topic":"Liver Diseases and Immunity","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"","keywords":"Kappa; Agonist; κ-opioid receptor; Medicine; Opioid; Pharmacology; Receptor; Internal medicine; Mathematics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001698553,0.0007856959,0.004863047,0.001378269,0.0002601453,0.001173131,0.001170958,0.00123055,0.004634841],"category_scores_gemma":[0.006483869,0.0003994554,0.005887738,0.001694693,0.0003752858,0.0008480609,0.0005390895,0.0009467703,0.0002848882],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007906476,"about_ca_system_score_gemma":0.002215761,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004967171,"about_ca_topic_score_gemma":0.02078399,"domain_scores_codex":[0.9990754,0.000271992,0.0003263851,0.0001199968,0.0001493505,0.00005684226],"domain_scores_gemma":[0.9970152,0.00204306,0.0006307215,0.00004292801,0.0002098686,0.00005813408],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"systematic_review","study_design_scores_codex":[0.002434894,0.00009200226,0.0008946399,0.8603415,0.03516486,0.00011328,0.00008778918,0.0002405526,0.0004818267,0.0001855024,0.004083966,0.09587915],"study_design_scores_gemma":[0.006528245,0.002430013,0.01445114,0.5103511,0.4195502,0.0008246032,0.0003711805,0.0003447227,0.0005492644,0.0006359837,0.04383577,0.0001276147],"study_design_candidate":"systematic_review","study_design_consensus":"systematic_review","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0009282817,0.9984364,0.00006241378,0.000111243,0.00007983255,0.00006110132,0.0001654519,0.000003819707,0.0001514229],"genre_scores_gemma":[0.01285938,0.9857352,0.0002845909,0.0006728437,0.0001014824,0.00007544512,0.0001380682,0.000002438443,0.0001304582],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004967171,"threshold_uncertainty_score":0.01550502,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02571790197318367,"score_gpt":0.3092525472809461,"score_spread":0.2835346453077625,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}