{"id":"W4249216413","doi":"10.2196/30737","title":"Novel Kappa-Opioid Receptor Agonist for the Treatment of Cholestatic Pruritus: Systematic Review","year":2022,"lang":"en","type":"article","venue":"JMIR Dermatology","topic":"Liver Diseases and Immunity","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"","keywords":"Kappa; Agonist; κ-opioid receptor; Medicine; Opioid; Pharmacology; Receptor; Internal medicine; Mathematics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001012184,0.0001298289,0.0007057773,0.00004019733,0.0002120943,0.000005037279,0.0001551107,0.00002716804,0.0002218465],"category_scores_gemma":[0.00005238975,0.00007997443,0.0002462399,0.0001289696,0.0000693859,0.00002100172,0.00003971381,0.00007580096,0.00001685191],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000107187,"about_ca_system_score_gemma":0.0001324477,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003933351,"about_ca_topic_score_gemma":0.000001444968,"domain_scores_codex":[0.9989214,0.0001295577,0.0004791637,0.0001429501,0.0001470714,0.0001798376],"domain_scores_gemma":[0.9987718,0.0003296777,0.0002493926,0.0005209276,0.00006987054,0.00005835513],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004880636,0.00691925,0.002231224,0.9374594,0.001727463,0.00004704399,0.003520149,0.000005372716,0.001475487,0.002425841,0.04219931,0.001501355],"study_design_scores_gemma":[0.02793858,0.009699727,0.01185983,0.06509357,0.02144029,0.01099477,0.01176149,0.003983563,0.002837782,0.000381286,0.8327221,0.001286955],"study_design_candidate":"systematic_review","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.2011715,0.6803797,0.003720503,0.04768758,0.001763452,0.06225732,0.001824842,0.0002930281,0.0009020408],"genre_scores_gemma":[0.8509862,0.06812558,0.003328411,0.0180786,0.0002223539,0.05176337,0.001491343,0.0001826061,0.005821504],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.8723659,"threshold_uncertainty_score":0.3261263,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02571790197318367,"score_gpt":0.3092525472809461,"score_spread":0.2835346453077625,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}