{"id":"W4249335081","doi":"10.1200/jco.2017.35.15_suppl.tps4132","title":"CheckMate 649: A randomized, multicenter, open-label, phase 3 study of nivolumab (nivo) + ipilimumab (ipi) or nivo + chemotherapy (CTX) vs CTX alone in pts with previously untreated advanced (adv) gastric (G) or gastroesophageal junction (GEJ) cancer.","year":2017,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre intégré universitaire de santé et de services sociaux de la Mauricie-et-du-Centre-du-Québec","funders":"","keywords":"Medicine; Nivolumab; Ipilimumab; Internal medicine; Cancer; Refractory (planetary science); Oncology; Phases of clinical research; Chemotherapy; Gastroenterology; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001219544,0.001270951,0.001449668,0.0004277863,0.0003721275,0.001265683,0.0008717722,0.001497087,0.008307415],"category_scores_gemma":[0.001088078,0.0005393405,0.001526279,0.0003636776,0.0007033793,0.0008532656,0.0003755648,0.002867431,0.001235876],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008220656,"about_ca_system_score_gemma":0.001099068,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001161204,"about_ca_topic_score_gemma":0.003625389,"domain_scores_codex":[0.9997526,0.0001274697,0.0000111423,0.00004425227,0.00002036901,0.0000441853],"domain_scores_gemma":[0.9994543,0.0001222591,0.0001457824,0.00003269478,0.00002971578,0.0002152352],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9340525,0.01862975,0.001328808,0.0009844487,0.00123706,0.00007508529,0.00008468813,0.0008132084,0.009537984,0.0002948968,0.003622438,0.02933914],"study_design_scores_gemma":[0.9336733,0.06150525,0.001903488,0.00003799604,0.0004023051,0.00004311276,0.00001825408,0.0005298681,0.0005218675,0.0001505922,0.0011981,0.00001583725],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9802188,0.00473068,0.0009807933,0.001053796,0.0006712756,0.005079293,0.003170399,0.0003416995,0.003753286],"genre_scores_gemma":[0.9799172,0.002632112,0.001889114,0.002074303,0.0003569557,0.004824294,0.002933685,0.00006038297,0.005311827],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008307415,"threshold_uncertainty_score":0.02779108,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.116826816991291,"score_gpt":0.4915325814690506,"score_spread":0.3747057644777596,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}