{"id":"W4249489511","doi":"10.1016/j.xphs.2017.02.009","title":"Safety and Biosimilarity of ior®LeukoCIM Compared to Neupogen® Based on Toxicity, Pharmacodynamic, and Pharmacokinetic Studies in the Sprague-Dawley Rat","year":2017,"lang":"en","type":"article","venue":"Journal of Pharmaceutical Sciences","topic":"Neutropenia and Cancer Infections","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"Nucro Technics","funders":"","keywords":"Pharmacodynamics; Pharmacokinetics; Filgrastim; Pharmacology; Adverse effect; Bioequivalence; Medicine; Biosimilar; Toxicity; Toxicokinetics; Dosing; Internal medicine; Neutropenia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005139107,0.0003648314,0.0004416148,0.0006249377,0.0001600198,0.0004509369,0.0002317901,0.0003887694,0.001336353],"category_scores_gemma":[0.0005795882,0.0001796514,0.000483796,0.0002705875,0.0004618374,0.0005001735,0.0001250925,0.0009686965,0.0002153671],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004119123,"about_ca_system_score_gemma":0.0005435852,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008616844,"about_ca_topic_score_gemma":0.0007708226,"domain_scores_codex":[0.9996895,0.0000744979,0.00002579145,0.00008005076,0.00008334002,0.0000469602],"domain_scores_gemma":[0.9993349,0.00008248809,0.0002962704,0.00006679032,0.00007975959,0.0001397186],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.03463833,0.003105527,0.002663391,0.0001325106,0.0001237137,0.0001874135,0.000148344,0.001050777,0.9299524,0.0004832827,0.0002834643,0.02723087],"study_design_scores_gemma":[0.002188836,0.1372285,0.02768585,0.00003942653,0.0005675604,0.0007934875,0.0002390447,0.007153739,0.8198887,0.0005773444,0.003550434,0.00008695143],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977343,0.0006294043,0.0007567041,0.00005857684,0.00002340765,0.00003513463,0.0003323919,0.00003209547,0.0003977952],"genre_scores_gemma":[0.9968165,0.0005232371,0.0005893504,0.0000560884,0.00002638234,0.0000422886,0.0004111034,0.00001783065,0.001517387],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001336353,"threshold_uncertainty_score":0.004470587,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1655454321708564,"score_gpt":0.4839409079420937,"score_spread":0.3183954757712373,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}