{"id":"W4249489511","doi":"10.1016/j.xphs.2017.02.009","title":"Safety and Biosimilarity of ior®LeukoCIM Compared to Neupogen® Based on Toxicity, Pharmacodynamic, and Pharmacokinetic Studies in the Sprague-Dawley Rat","year":2017,"lang":"en","type":"article","venue":"Journal of Pharmaceutical Sciences","topic":"Neutropenia and Cancer Infections","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"Nucro Technics","funders":"","keywords":"Pharmacodynamics; Pharmacokinetics; Filgrastim; Pharmacology; Adverse effect; Bioequivalence; Medicine; Biosimilar; Toxicity; Toxicokinetics; Dosing; Internal medicine; Neutropenia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001695874,0.0001395322,0.0004080798,0.0001722306,0.0003864462,0.00007589249,0.0003313348,0.00002816405,0.00005566607],"category_scores_gemma":[0.0002092952,0.00008090728,0.00007438573,0.0002324932,0.001074695,0.0001826482,0.0001007498,0.0003644853,0.000001066888],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005724492,"about_ca_system_score_gemma":0.0001105455,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001782579,"about_ca_topic_score_gemma":0.00002752447,"domain_scores_codex":[0.9984654,0.0001491961,0.000428332,0.000192155,0.0005294213,0.0002354586],"domain_scores_gemma":[0.9988914,0.0003589204,0.0002458292,0.000134556,0.000138045,0.0002312491],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005107971,0.001498447,0.524924,0.0005029647,0.00026938,0.0003927449,0.001874567,0.001745677,0.4356825,0.0005473804,0.003676562,0.02377773],"study_design_scores_gemma":[0.02015314,0.004620729,0.6629483,0.00139284,0.00130859,0.0009261525,0.001862069,0.03102484,0.2420509,0.0005262551,0.03258817,0.0005980285],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9764807,0.0009179275,0.00004832263,0.02007745,0.0005660311,0.0003240703,0.000007071986,0.000004412915,0.001574013],"genre_scores_gemma":[0.9945955,0.001549332,0.0001848906,0.003493943,0.0001510991,0.000003563707,1.167169e-7,0.000004501462,0.00001703237],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1936316,"threshold_uncertainty_score":0.3959757,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1655454321708564,"score_gpt":0.4839409079420937,"score_spread":0.3183954757712373,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}