{"id":"W4249585631","doi":"10.21203/rs.3.rs-26216/v1","title":"The relationship between immune status as measured by stimulated ex-vivo tumour necrosis factor alpha levels and the acquisition of nosocomial infections in critically ill mechanically ventilated patients.","year":2020,"lang":"en","type":"preprint","venue":"Research Square","topic":"Nosocomial Infections in ICU","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Kingston Health Sciences Centre; Queen's University","funders":"Southeastern Ontario Academic Medical Organization; Lotte and John Hecht Memorial Foundation","keywords":"Critically ill; Ex vivo; Immune system; Tumor necrosis factor alpha; Medicine; Immune status; In vivo; Alpha (finance); Immunology; Intensive care medicine; Biology; Surgery","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001919193,0.0004230076,0.0008370373,0.0001893623,0.0001865939,0.0006576763,0.0002709102,0.0006582484,0.001348412],"category_scores_gemma":[0.003164817,0.0002671606,0.0005633762,0.0002250231,0.0003068445,0.0004075566,0.0003084448,0.0009047545,0.0001076976],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002826925,"about_ca_system_score_gemma":0.0003563577,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000137439,"about_ca_topic_score_gemma":0.0002084706,"domain_scores_codex":[0.9992836,0.0003324582,0.00009203162,0.0001228155,0.00009461963,0.00007451491],"domain_scores_gemma":[0.996192,0.001307573,0.001543742,0.0002048078,0.0001980036,0.000553955],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.4225643,0.005964817,0.5373464,0.0008228175,0.002072188,0.0001236952,0.0001417186,0.0005677635,0.01174271,0.00006640481,0.0003735502,0.0182137],"study_design_scores_gemma":[0.02195973,0.140434,0.8307389,0.00008545358,0.001196886,0.0003252694,0.0001147987,0.001278467,0.003149985,0.0001496287,0.0005227198,0.0000442321],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998857,0.000754035,0.00007799071,0.00003494247,0.00001441795,0.00005365323,0.0001210362,0.000001831181,0.00008517796],"genre_scores_gemma":[0.9993001,0.0001340227,0.0001678845,0.00005245901,0.00002259136,0.00008000142,0.0001557373,6.924423e-7,0.00008633],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001919193,"threshold_uncertainty_score":0.01014978,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09622486288620838,"score_gpt":0.4046275402009222,"score_spread":0.3084026773147138,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}