{"id":"W4249641409","doi":"10.26434/chemrxiv-2021-qgnfh","title":"Pharmaceutical Solid Form Formation via Vapour-Assisted Tumbling (VAT) – A Solvent Efficient Process with Potential Industrial Applications","year":2021,"lang":"en","type":"preprint","venue":"ChemRxiv","topic":"Crystallization and Solubility Studies","field":"Materials Science","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Apotex Pharmachem (Canada)","funders":"","keywords":"Solvent; Process engineering; Mechanochemistry; Process (computing); Differential scanning calorimetry; Materials science; Chemical engineering; Nanotechnology; Computer science; Chemistry; Organic chemistry; Engineering; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004935878,0.0003870116,0.0005278278,0.0001173549,0.0004506506,0.0004388357,0.0003968384,0.0003320034,0.0003798732],"category_scores_gemma":[0.00008202489,0.0003464214,0.0001689722,0.0003547704,0.0001931663,0.0001566774,0.0005412544,0.0005469398,0.00002743837],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002885585,"about_ca_system_score_gemma":0.0004105828,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001428631,"about_ca_topic_score_gemma":0.0000292072,"domain_scores_codex":[0.9972574,0.00006879398,0.0007143171,0.0007813199,0.0006997919,0.0004783566],"domain_scores_gemma":[0.9981731,0.00004776208,0.0004304706,0.0005241318,0.0006384184,0.0001861876],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009961842,0.00482099,0.0005369775,0.005617314,0.0005271726,0.00008687798,0.01321728,0.141249,0.8196039,0.0003328273,0.0007063232,0.01230518],"study_design_scores_gemma":[0.00558377,0.0001526115,0.0006711511,0.001152978,0.0009773789,0.0001731803,0.005492359,0.2327209,0.7462572,0.0006390778,0.003944332,0.00223509],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7394063,0.0001540459,0.2574381,0.000459138,0.0005106991,0.001440638,0.00001807807,0.000239046,0.0003339315],"genre_scores_gemma":[0.9971486,0.0000303388,0.0009558319,0.00009450873,0.0004151624,0.0009123191,0.0003473201,0.00003682385,0.00005908548],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2577423,"threshold_uncertainty_score":0.9998988,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0638881695518435,"score_gpt":0.3326266276901013,"score_spread":0.2687384581382578,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}