{"id":"W4249749535","doi":"10.1002/ange.201607431","title":"Structural Snapshots for Mechanism‐Based Inactivation of a Glycoside Hydrolase by Cyclopropyl Carbasugars","year":2016,"lang":"en","type":"article","venue":"Angewandte Chemie","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"","keywords":"Chemistry; Stereochemistry; Glycoside hydrolase; Anomer; Reactivity (psychology); Mechanism (biology); Covalent bond; Glycoside; Carbon atom; Combinatorial chemistry; Enzyme; Biochemistry; Organic chemistry; Philosophy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000130026,0.0003815521,0.0003011993,0.0003375285,0.0006336152,0.0005427925,0.0007955756,0.0007583675,0.008791371],"category_scores_gemma":[0.0002501157,0.0003598563,0.0003349494,0.0002933731,0.0003828625,0.000438923,0.0002962711,0.001569974,0.0003187821],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001316065,"about_ca_system_score_gemma":0.0005819039,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00374717,"about_ca_topic_score_gemma":0.00379827,"domain_scores_codex":[0.9998976,0.00000751094,0.000002663849,0.00000962991,0.0000315089,0.00005110484],"domain_scores_gemma":[0.9998426,0.00004649602,0.00003027279,0.00001676571,0.00001733374,0.00004652023],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003710505,0.001334091,0.006622333,0.0008015122,0.0002737235,0.005808417,0.001676348,0.1171688,0.8139608,0.01760826,0.01109207,0.01994317],"study_design_scores_gemma":[0.0008601602,0.004540189,0.05417758,0.0001640976,0.0002652882,0.001622912,0.001471988,0.4935481,0.4152641,0.008750175,0.01905479,0.0002806286],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9830119,0.0005966451,0.00296387,0.000594622,0.00007449586,0.00003862624,0.001207986,0.0005556159,0.01095613],"genre_scores_gemma":[0.9964088,0.0003452257,0.00149531,0.00003960409,0.000009014459,0.00002289806,0.00080067,0.00005107166,0.0008274239],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008791371,"threshold_uncertainty_score":0.02941,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01455996701873285,"score_gpt":0.2256701620806114,"score_spread":0.2111101950618786,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}