{"id":"W4249844052","doi":"10.1172/jci0215316","title":"Different mechanisms underlying the stimulation of KCa channels by nitric oxide and carbon monoxide","year":2002,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada","keywords":"Nitric oxide; Chemistry; Biophysics; Stimulation; Protein subunit; Carbon monoxide; Pharmacology; Agonist; Biochemistry; Internal medicine; Medicine; Biology; Receptor; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006631477,0.0000880298,0.0001874484,0.00005171387,0.00004948613,0.00001712034,0.00007205946,0.0001513679,0.000009702626],"category_scores_gemma":[0.0005230896,0.00005987946,0.00009795377,0.00008122931,0.00009263909,0.00001161753,0.00002239395,0.0001431842,4.515507e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009253467,"about_ca_system_score_gemma":0.00001625733,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005493706,"about_ca_topic_score_gemma":8.782965e-7,"domain_scores_codex":[0.99867,0.000185737,0.0007440963,0.0001153796,0.0002049899,0.00007980346],"domain_scores_gemma":[0.9988099,0.0001139226,0.0007047331,0.000103757,0.0001770237,0.00009060043],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001706871,0.000139458,0.01227393,0.00002903186,0.0001214339,7.955486e-7,0.0001180624,0.003895715,0.9715412,0.0004916135,0.002837302,0.008380724],"study_design_scores_gemma":[0.005077997,0.002572442,0.2230783,0.0001982124,0.0003103967,0.00007275939,0.0004750231,0.3514709,0.3921426,0.02167124,0.002425796,0.0005044407],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.986129,0.0003560353,0.01228552,0.0007040381,0.0003709399,0.00009702395,0.000001282536,0.000002902051,0.00005319868],"genre_scores_gemma":[0.9986838,0.000290985,0.0003432041,0.0002491465,0.0001966286,0.000001671993,0.000009914683,0.000008767067,0.0002158872],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5793987,"threshold_uncertainty_score":0.2441813,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09247713089352295,"score_gpt":0.3271748391372642,"score_spread":0.2346977082437413,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}