{"id":"W4249951417","doi":"10.2174/13892002130106","title":"Why We Need Proper PBPK Models to Examine Intestine and Liver Oral Drug Absorption","year":2012,"lang":"en","type":"article","venue":"Current Drug Metabolism","topic":"Analytical Chemistry and Chromatography","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Physiologically based pharmacokinetic modelling; Bioavailability; Pharmacokinetics; Pharmacology; Transporter; Small intestine; Metabolite; Chemistry; Drug; Biology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002140852,0.0003494211,0.0003908857,0.00008491201,0.00009925386,0.00006249693,0.0002392756,0.00008391071,0.0007595012],"category_scores_gemma":[0.00005379071,0.0002894462,0.0001364014,0.0002857292,0.0001212613,0.0004349318,0.0001981342,0.0003578674,0.00008173568],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002429736,"about_ca_system_score_gemma":0.00001703021,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004317862,"about_ca_topic_score_gemma":0.000003130611,"domain_scores_codex":[0.9983568,0.00003210323,0.0003432737,0.0004014331,0.0003237631,0.0005426041],"domain_scores_gemma":[0.9988294,0.00005214295,0.00009071571,0.0003707392,0.0001096475,0.0005473203],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005115538,0.004753841,0.01433383,0.005334271,0.0006976061,0.00002539919,0.01998467,0.0002559126,0.4975403,0.01877059,0.287122,0.1506701],"study_design_scores_gemma":[0.002057335,0.000009656112,0.001247876,0.0005729604,0.0007485218,0.00004910297,0.00115331,0.008015377,0.254302,0.00221248,0.7280381,0.001593249],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9705374,0.02287171,0.001053615,0.0006882024,0.0003455393,0.0001521092,0.00004489107,0.0001965323,0.004109997],"genre_scores_gemma":[0.9958543,0.0006772254,0.0005381583,0.0002044379,0.0008642158,0.00004961679,0.00006174858,0.00003978971,0.001710534],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4409161,"threshold_uncertainty_score":0.9999558,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03841830878905437,"score_gpt":0.2579574091466965,"score_spread":0.2195391003576422,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}