{"id":"W4249951417","doi":"10.2174/13892002130106","title":"Why We Need Proper PBPK Models to Examine Intestine and Liver Oral Drug Absorption","year":2012,"lang":"en","type":"article","venue":"Current Drug Metabolism","topic":"Analytical Chemistry and Chromatography","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Physiologically based pharmacokinetic modelling; Bioavailability; Pharmacokinetics; Pharmacology; Transporter; Small intestine; Metabolite; Chemistry; Drug; Biology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001469158,0.0009407341,0.001866964,0.0004101915,0.0002185526,0.001710867,0.001695367,0.001935511,0.001612141],"category_scores_gemma":[0.00375715,0.0006707378,0.001530078,0.0003795028,0.0007844002,0.003982137,0.0007435161,0.002977363,0.001218575],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000735759,"about_ca_system_score_gemma":0.001431878,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00447788,"about_ca_topic_score_gemma":0.002599047,"domain_scores_codex":[0.9995346,0.0002042057,0.00003307069,0.00008353891,0.0001017218,0.00004275247],"domain_scores_gemma":[0.9989961,0.0005667913,0.0001163731,0.0000815055,0.000192462,0.00004684844],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0005917388,0.0003283496,0.006679867,0.00288097,0.0004952667,0.0008140111,0.0003241614,0.6498339,0.04446988,0.134972,0.01844213,0.1401678],"study_design_scores_gemma":[0.0001863882,0.0003361047,0.002250181,0.0003306815,0.0002436765,0.0007036357,0.0001789272,0.8168482,0.007151085,0.1227227,0.04893589,0.0001125372],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.0367472,0.01526573,0.924936,0.01264009,0.0004245182,0.0002219834,0.001152031,0.0012668,0.007345685],"genre_scores_gemma":[0.5675935,0.04614138,0.3677572,0.006193611,0.0008457242,0.001178172,0.001345303,0.0009784932,0.00796665],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.00447788,"threshold_uncertainty_score":0.008903623,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03841830878905437,"score_gpt":0.2579574091466965,"score_spread":0.2195391003576422,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}