{"id":"W4249989858","doi":"10.1007/978-1-4614-6438-9_101763-1","title":"DREAM (Downstream Regulatory Element Antagonist Modulator)","year":2016,"lang":"en","type":"book-chapter","venue":"","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Downstream (manufacturing); Dream; Antagonist; Chemistry; Engineering; Psychology; Neuroscience; Operations management; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002163251,0.0005405036,0.0004285129,0.0004555084,0.0002402238,0.0007776975,0.0007737988,0.0004799211,0.0184215],"category_scores_gemma":[0.0001687488,0.0002088552,0.0002785367,0.0004031824,0.0002734924,0.0007566917,0.0007126684,0.001382146,0.01529873],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003397411,"about_ca_system_score_gemma":0.0002603949,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001991129,"about_ca_topic_score_gemma":0.0004875835,"domain_scores_codex":[0.9999179,0.000007271957,0.000004473203,0.00002372348,0.00003692026,0.000009709181],"domain_scores_gemma":[0.9999741,0.000008082831,0.000003315214,0.000003660541,0.000005407277,0.000005374436],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002510089,0.00006458249,0.00014702,0.001084156,0.00002286413,0.0002933404,0.0001036984,0.0007189782,0.08871373,0.07105172,0.1048254,0.7327235],"study_design_scores_gemma":[0.00001033295,0.00003686693,0.0001486155,0.00008092324,0.00001250038,0.0004971452,0.00002158858,0.0001961723,0.01493636,0.006031289,0.9780181,0.00001008115],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"other","genre_gemma":"methods","genre_scores_codex":[0.01143116,0.3462992,0.07396299,0.005029994,0.00740486,0.0001458162,0.003392996,0.003186978,0.549146],"genre_scores_gemma":[0.0360964,0.1244522,0.0342062,0.002370958,0.0009838445,0.0001948288,0.002453758,0.0004005399,0.7988412],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.0184215,"threshold_uncertainty_score":0.06162608,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008643076896907671,"score_gpt":0.2146765613148164,"score_spread":0.2060334844179087,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}