{"id":"W4250047821","doi":"10.1016/j.jalz.2016.06.608","title":"O4‐01‐03: AMYLOID‐B AND HYPERPHOSPHORYLATED TAU SYNERGY DRIVES CLINICAL PROGRESSION TO ALZHEIMER’S DISEASE","year":2016,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill Genome Centre; Montreal Neurological Institute and Hospital; Douglas Mental Health University Institute; McGill University","funders":"","keywords":"Dementia; Neuropsychology; Oncology; Internal medicine; Positron emission tomography; Psychology; Biomarker; Voxel; Clinical Dementia Rating; Logistic regression; Cognition; Medicine; Disease; Neuroscience; Biology; Radiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001604186,0.0003903827,0.0004897089,0.0005193012,0.0004113255,0.0009443788,0.000706176,0.000805314,0.009217689],"category_scores_gemma":[0.00379212,0.0002795247,0.0005083493,0.0005035304,0.0005927845,0.0006066354,0.0007378616,0.0007803649,0.00104993],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003011459,"about_ca_system_score_gemma":0.0008775289,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002592949,"about_ca_topic_score_gemma":0.001388853,"domain_scores_codex":[0.9994106,0.0002181306,0.00004289434,0.000143667,0.00007532824,0.0001094203],"domain_scores_gemma":[0.9972645,0.0009621126,0.0007407898,0.0002454521,0.0002371519,0.0005499496],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01066001,0.0008482125,0.9585292,0.00005585199,0.0002008838,0.001137294,0.0004381651,0.0007084253,0.01532623,0.0005812204,0.0009999224,0.01051449],"study_design_scores_gemma":[0.000166973,0.001254665,0.9867495,0.00001834468,0.0001191018,0.00205746,0.0004329266,0.004081564,0.001956419,0.002235967,0.0009098093,0.00001722163],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983381,0.00004971946,0.0002477413,0.0002287255,0.000006544809,0.00000670596,0.0001777564,0.00001331395,0.0009313407],"genre_scores_gemma":[0.998944,0.0000177276,0.0002141068,0.00004465909,0.000013362,0.000009060756,0.0001624194,0.000008607341,0.0005861043],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009217689,"threshold_uncertainty_score":0.03083622,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03691428160539173,"score_gpt":0.3597741167809861,"score_spread":0.3228598351755944,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}