{"id":"W4250083193","doi":"10.12688/gatesopenres.13304.1","title":"A multi-center, adaptive, randomized, platform trial to evaluate the effect of repurposed medicines in outpatients with early coronavirus disease 2019 (COVID-19) and high-risk for complications: the TOGETHER master trial protocol","year":2021,"lang":"en","type":"preprint","venue":"Gates Open Research","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; McMaster University","funders":"Rainwater Charitable Foundation; Fast Grants; Bill and Melinda Gates Foundation","keywords":"Medicine; Interim analysis; Randomized controlled trial; Clinical endpoint; Clinical trial; Surrogate endpoint; Data monitoring committee; Placebo; Intensive care medicine; Emergency medicine; Internal medicine; Alternative medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006514637,0.003836053,0.00397612,0.0005874165,0.0009812083,0.001469197,0.001907937,0.003282384,0.01660276],"category_scores_gemma":[0.006393596,0.001071851,0.002588219,0.0005522651,0.001761491,0.002114017,0.001183324,0.00376275,0.002063442],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001115506,"about_ca_system_score_gemma":0.00270538,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006849627,"about_ca_topic_score_gemma":0.001293387,"domain_scores_codex":[0.9972692,0.001682388,0.0001611141,0.0003634635,0.0001818981,0.000341939],"domain_scores_gemma":[0.9965345,0.0009450333,0.0009427635,0.0003905163,0.0003216067,0.0008656616],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9862126,0.004987183,0.0004231643,0.0005283663,0.0005744607,0.00002719084,0.00003831058,0.0003369616,0.001003994,0.0002545406,0.001696393,0.003916843],"study_design_scores_gemma":[0.9641007,0.03289551,0.0007980507,0.00004808846,0.0002314551,0.00001574062,0.00001333518,0.0004445461,0.0001938832,0.0003554123,0.0008882794,0.00001496757],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"protocol","genre_scores_codex":[0.6422407,0.003530069,0.005045526,0.004305164,0.002397885,0.3216872,0.01059172,0.0005058799,0.009695926],"genre_scores_gemma":[0.5228178,0.001736326,0.01692395,0.005572378,0.001612215,0.4349972,0.005829006,0.0001052524,0.01040595],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.01660276,"threshold_uncertainty_score":0.05554175,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2866131805862153,"score_gpt":0.5075914495481564,"score_spread":0.2209782689619411,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}