{"id":"W4250185678","doi":"10.26434/chemrxiv.7212836.v1","title":"An Activity-based Probe Targeting Non-catalytic, Highly Conserved Amino Acid Residues Within Bromodomains","year":2018,"lang":"en","type":"preprint","venue":"ChemRxiv","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Novartis Pharma; Ministero dello Sviluppo Economico; Fundação de Amparo à Pesquisa do Estado de São Paulo; Medical Research Council; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; Ontario Ministry of Economic Development and Innovation; Genome Canada; Pfizer","keywords":"Bromodomain; Druggability; Small molecule; Bioorthogonal chemistry; Biochemistry; Lysine; Amino acid; Recombinant DNA; Chemistry; Transcription factor; Biology; Epigenetics; Endogeny; Alkyne; Cell biology; Computational biology; Gene; Combinatorial chemistry; Click chemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003995544,0.0004342781,0.0003193856,0.000180702,0.0001740405,0.0003478774,0.000482291,0.0007679032,0.001009946],"category_scores_gemma":[0.0002708456,0.000192275,0.0002555092,0.0001222094,0.0004254642,0.0002689438,0.0002678212,0.0009257562,0.0004260387],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004985349,"about_ca_system_score_gemma":0.0002728238,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003400693,"about_ca_topic_score_gemma":0.0003451188,"domain_scores_codex":[0.999782,0.00004086063,0.000009135586,0.0000752572,0.00004785135,0.00004493461],"domain_scores_gemma":[0.9998154,0.00006862965,0.00004746978,0.00002322199,0.00001656851,0.00002875181],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002761193,0.000005720536,0.00002524755,0.00003040651,0.000002055245,0.00002244027,0.00001047755,0.00003096497,0.9991824,0.0001340584,0.00002226982,0.0005063448],"study_design_scores_gemma":[0.000004941416,0.00004419763,0.0001522524,0.000001281529,0.00000304731,0.00007687771,0.000003667221,0.0001514273,0.9984894,0.00001542908,0.00105577,0.000001628562],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8927259,0.003706181,0.09620163,0.0006284823,0.0001008053,0.0001529204,0.0005080453,0.0004316259,0.005544393],"genre_scores_gemma":[0.9551245,0.001474577,0.03568466,0.0002367053,0.00002751692,0.0001031369,0.0003962404,0.00005773178,0.006894869],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001009946,"threshold_uncertainty_score":0.003617108,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01658239049640154,"score_gpt":0.2603922376318082,"score_spread":0.2438098471354067,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}