{"id":"W4250295959","doi":"10.3410/f.1070817.523752","title":"Faculty Opinions recommendation of D1-D2 dopamine receptor heterooligomers with unique pharmacology are coupled to rapid activation of Gq/11 in the striatum.","year":2007,"lang":"en","type":"dataset","venue":"Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research","keywords":"Dopamine receptor D2; Agonist; Dopamine receptor D1; Dopamine; Dopamine receptor; Receptor; Chemistry; G protein-coupled receptor; Partial agonist; Pharmacology; Dopamine receptor D3; D1-like receptor; Neuroscience; Biology; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006080875,0.000884769,0.0005281246,0.002832884,0.0003374374,0.0008463439,0.000949631,0.0005094726,0.02882555],"category_scores_gemma":[0.004165702,0.0002083476,0.000473925,0.004273478,0.0001397529,0.0005758088,0.000569613,0.0007424729,0.0158704],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001010871,"about_ca_system_score_gemma":0.001762101,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01596497,"about_ca_topic_score_gemma":0.03920849,"domain_scores_codex":[0.9993154,0.00007559156,0.00006320827,0.0001761854,0.0002880281,0.00008158319],"domain_scores_gemma":[0.9981255,0.0004654078,0.0003513069,0.00028,0.0005892307,0.0001884577],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002343034,0.00006261908,0.01851284,0.0009939108,0.0001301009,0.0001131882,0.00005932705,0.001180136,0.001917136,0.001209282,0.946945,0.02864212],"study_design_scores_gemma":[0.0001892705,0.0000391771,0.05675435,0.0001395701,0.00007598721,0.0001388422,0.0001189422,0.003471063,0.004981382,0.0008201589,0.9332392,0.00003214597],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"dataset","genre_gemma":"dataset","genre_scores_codex":[0.004279719,0.0001011062,0.0003189181,0.0002175646,0.0000276992,0.00003087471,0.9907441,0.0006833323,0.003596826],"genre_scores_gemma":[0.00477483,0.00009215187,0.0008906008,0.00003766313,0.000009051072,0.00006226286,0.9923653,0.00006397879,0.001704211],"genre_candidate":"dataset","genre_consensus":"dataset","teacher_disagreement_score":0.02882555,"threshold_uncertainty_score":0.09643108,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02426472697804012,"score_gpt":0.3400855980860841,"score_spread":0.315820871108044,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}