{"id":"W4250327340","doi":"10.1093/ibd/izy393.068","title":"P062 DOSE ESCALATION WITH ORIGINATOR INFLIXIMAB OR COMBINATION THERAPY WITH ORIGINATOR INFLIXIMAB AND IMMUNOMODULATORS SIGNIFICANTLY INCREASES RISK FOR SERIOUS ADVERSE EVENTS IN PEDIATRIC IBD – THE DEVELOP EXPERIENCE","year":2019,"lang":"en","type":"article","venue":"Inflammatory Bowel Diseases","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Infliximab; Medicine; Ulcerative colitis; Adverse effect; Inflammatory bowel disease; Internal medicine; Crohn's disease; Adverse Event Reporting System; Observational study; Disease; Pediatrics","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002038233,0.000181192,0.000327843,0.0004850011,0.0001600834,0.0005750114,0.000273163,0.0001991193,0.001445898],"category_scores_gemma":[0.006568542,0.0001675054,0.0007759709,0.0009748557,0.0001899565,0.0005391717,0.0005916241,0.0005363986,0.0002014635],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002610673,"about_ca_system_score_gemma":0.0003743106,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008623974,"about_ca_topic_score_gemma":0.00140113,"domain_scores_codex":[0.9977747,0.0009616881,0.00024682,0.0003337019,0.0005658594,0.0001173487],"domain_scores_gemma":[0.9917104,0.002301144,0.004460407,0.0006922708,0.0004446739,0.0003912905],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006485026,0.00004766108,0.9890621,0.00003596305,0.0001690301,0.00009435895,0.00004605983,0.00009411145,0.0001619325,0.00004073338,0.0006877879,0.008911792],"study_design_scores_gemma":[0.0000633956,0.0005295774,0.9968167,0.00001731791,0.0001156144,0.0005522367,0.00006001339,0.0002542238,0.000272917,0.00002741591,0.001286554,0.000004108809],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953213,0.0007570358,0.0004189348,0.00009754464,0.000009642784,0.00003891884,0.002105692,0.00001305216,0.00123786],"genre_scores_gemma":[0.9951903,0.0006105721,0.0005732658,0.0001146062,0.00004034059,0.00004555669,0.003105544,0.00001248358,0.0003074295],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002038233,"threshold_uncertainty_score":0.01077938,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004987939920094087,"score_gpt":0.2262399349964858,"score_spread":0.2212519950763917,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}