{"id":"W4250431719","doi":"10.1210/en.142.2.580","title":"Estradiol Regulates Gonadotropin-Releasing Hormone (GnRH) and its Receptor Gene Expression and Antagonizes the Growth Inhibitory Effects of GnRH in Human Ovarian Surface Epithelial and Ovarian Cancer Cells","year":2001,"lang":"en","type":"article","venue":"Endocrinology","topic":"Ovarian cancer diagnosis and treatment","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Internal medicine; Endocrinology; Estrogen receptor; Autocrine signalling; Estrogen; GNRHR; Biology; Messenger RNA; Gonadotropin-releasing hormone; Receptor; Estrogen receptor alpha; Hormone; Luteinizing hormone; Gene; Cancer; Medicine; Breast cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001075257,0.0001714298,0.000217909,0.0001765632,0.00009477253,0.000206281,0.00008564768,0.0001022337,0.0006338086],"category_scores_gemma":[0.0001156888,0.00009659064,0.0002426463,0.0001611771,0.0001428652,0.00009027204,0.0001091584,0.0001935486,0.0002066157],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001107687,"about_ca_system_score_gemma":0.0001445257,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006565073,"about_ca_topic_score_gemma":0.00109347,"domain_scores_codex":[0.9999166,0.00001419777,0.000009486082,0.00001302088,0.0000293607,0.00001731957],"domain_scores_gemma":[0.9999384,0.00001661512,0.0000142257,0.000008296228,0.0000134034,0.000009174613],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001233215,0.0000213716,0.001298717,0.00005908593,0.000007907804,0.0001294349,0.00003419246,0.00002916028,0.9955384,0.00005349761,0.00005806535,0.002646742],"study_design_scores_gemma":[0.000051731,0.0009114869,0.06310635,0.00001543256,0.00004804518,0.001095965,0.0002248898,0.0005953382,0.9241684,0.00006850265,0.009704491,0.000009351686],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906571,0.005607529,0.001689139,0.0001003767,0.00003747194,0.00002760805,0.0002517702,0.00002782267,0.00160131],"genre_scores_gemma":[0.9904464,0.00408297,0.00197568,0.0001205492,0.00002144684,0.00003393689,0.0007722506,0.00001348837,0.002533176],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006565073,"threshold_uncertainty_score":0.002120316,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0105805501004838,"score_gpt":0.2507197622623348,"score_spread":0.240139212161851,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}