{"id":"W4250460935","doi":"10.21203/rs.3.rs-469320/v1","title":"Confirmatory Efficacy and Safety Trial of Magnetic Seizure Therapy for Depression (CREST – MST): Study Protocol for a Randomized Non-Inferiority Trial of Magnetic Seizure Therapy versus Electroconvulsive Therapy","year":2021,"lang":"en","type":"preprint","venue":"Research Square","topic":"Electroconvulsive Therapy Studies","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Addiction and Mental Health; University of Toronto; Simon Fraser University","funders":"National Institute of Mental Health","keywords":"Electroconvulsive therapy; Randomized controlled trial; Major depressive disorder; Adverse effect; Depression (economics); Suicidal ideation; Clinical endpoint; Seizure threshold; Psychiatry; Medicine; Treatment-resistant depression; Psychology; Internal medicine; Cognition; Poison control; Epilepsy; Injury prevention; Emergency medicine; Anticonvulsant","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01340183,0.005314483,0.005732249,0.001090574,0.001868245,0.002121966,0.002212019,0.004699855,0.03922017],"category_scores_gemma":[0.01130891,0.001784147,0.002827181,0.001115694,0.002651345,0.002109784,0.0009579171,0.005052759,0.007061161],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001991047,"about_ca_system_score_gemma":0.006259014,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008053918,"about_ca_topic_score_gemma":0.001890714,"domain_scores_codex":[0.9911971,0.005074263,0.0007265853,0.001220722,0.0007953602,0.0009859898],"domain_scores_gemma":[0.9948383,0.001184828,0.001316087,0.000776689,0.0007273544,0.001156845],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9762136,0.007090322,0.0003639163,0.001745165,0.0006922696,0.00009016314,0.00009501236,0.0004477688,0.001736596,0.0009208383,0.003495243,0.007109131],"study_design_scores_gemma":[0.9649833,0.02678038,0.0006857732,0.0001789344,0.0002928199,0.0000337089,0.00002135398,0.0006353831,0.0003729108,0.0007728141,0.005212815,0.00002975532],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.02635982,0.0007424861,0.002867204,0.0005974573,0.0007781225,0.963636,0.002177924,0.0001877374,0.002653254],"genre_scores_gemma":[0.03963546,0.0003891425,0.003921367,0.0009092224,0.0003002535,0.9523397,0.0006530342,0.00002395861,0.00182785],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.03922017,"threshold_uncertainty_score":0.1312046,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07470094111810956,"score_gpt":0.4527220143790247,"score_spread":0.3780210732609151,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}