{"id":"W4250480958","doi":"10.1002/ange.201510057","title":"Total Synthesis and Activity of the Metallo‐β‐lactamase Inhibitor Aspergillomarasmine A","year":2015,"lang":"en","type":"article","venue":"Angewandte Chemie","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research","keywords":"Serine; Chemistry; Enzyme; Nucleophile; Antibiotics; Stereochemistry; Metabolite; Combinatorial chemistry; Biochemistry; Catalysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000159865,0.0004030287,0.0002169177,0.0002665821,0.000225714,0.0002756253,0.0002261806,0.000270983,0.00185716],"category_scores_gemma":[0.0001770616,0.00009689802,0.0001934727,0.0002518972,0.000134562,0.0002719756,0.0002048613,0.000368154,0.0005837734],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002654228,"about_ca_system_score_gemma":0.0005496261,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004926165,"about_ca_topic_score_gemma":0.0006776493,"domain_scores_codex":[0.9998677,0.00002199717,0.00001470241,0.00002505267,0.00003307398,0.00003752365],"domain_scores_gemma":[0.9999062,0.00001578545,0.00001693835,0.00001422727,0.00001950938,0.00002727809],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001302096,0.00008412266,0.0001227769,0.0001115446,0.00001493205,0.0001063767,0.00002474957,0.0004452715,0.9910156,0.0006651066,0.0001203909,0.007159034],"study_design_scores_gemma":[0.00001350565,0.0003398039,0.000258466,0.000006278644,0.000008494883,0.00007266783,0.000005627286,0.0003393313,0.9954137,0.00007501354,0.00346229,0.000004821276],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9625769,0.006444141,0.01130932,0.0001562886,0.00009772726,0.0001255995,0.001556346,0.0002369164,0.0174968],"genre_scores_gemma":[0.9911221,0.001463713,0.00300977,0.00002720815,0.00001021271,0.00003312152,0.0006619956,0.00002636108,0.003645505],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00185716,"threshold_uncertainty_score":0.006212831,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01499736004493011,"score_gpt":0.2359631910261568,"score_spread":0.2209658309812267,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}