{"id":"W4250539658","doi":"10.1002/ange.201807629","title":"Metallaphotoredox Difluoromethylation of Aryl Bromides","year":2018,"lang":"en","type":"article","venue":"Angewandte Chemie","topic":"Fluorine in Organic Chemistry","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Janssen Research and Development; National Institute of General Medical Sciences; Japan Society for the Promotion of Science; Merck Sharp and Dohme; Ministerio de Economía y Competitividad; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Daiichi-Sankyo; Pfizer; Fonds de recherche du Québec – Nature et technologies; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Aryl; Chemistry; Silylation; Electrophile; Combinatorial chemistry; Halogen; Catalysis; Alkyl; Halide; Aryl radical; Photoredox catalysis; Organic chemistry; Photocatalysis","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003691468,0.0001867947,0.0002700914,0.00005594182,0.00009262862,0.000008018375,0.0002801166,0.0002932541,0.007113667],"category_scores_gemma":[0.0002261917,0.0001839312,0.0001097788,0.0002656122,0.0004357527,0.0000909415,0.0001095559,0.0003138845,0.000169151],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006076075,"about_ca_system_score_gemma":0.00005723561,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002510416,"about_ca_topic_score_gemma":0.000008273634,"domain_scores_codex":[0.9989042,0.00002385748,0.0003427253,0.0002750363,0.0001607377,0.0002934238],"domain_scores_gemma":[0.9989762,0.0002485397,0.000167424,0.0002999775,0.0001694828,0.000138317],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001002199,0.0001121521,0.004579992,0.00006282021,0.0001568572,0.000004401689,0.0002990593,0.000001165425,0.9846618,0.00007708529,0.008834653,0.001109818],"study_design_scores_gemma":[0.0006868263,0.0000693741,0.001026034,0.00001062652,0.0001175573,0.00001672736,0.00004307647,0.00002160689,0.9353181,0.0004394545,0.0620785,0.0001720878],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9642532,0.0005099653,0.00002195943,0.0002518922,0.000624742,0.0001391409,0.00004117153,0.00009688805,0.03406106],"genre_scores_gemma":[0.9958302,0.00009260607,0.0004933924,0.0002669187,0.000716572,0.00001530193,0.00003946743,0.00002863017,0.002516889],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05324385,"threshold_uncertainty_score":0.993794,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08743045432176431,"score_gpt":0.4036400938924435,"score_spread":0.3162096395706792,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}