{"id":"W4250539658","doi":"10.1002/ange.201807629","title":"Metallaphotoredox Difluoromethylation of Aryl Bromides","year":2018,"lang":"en","type":"article","venue":"Angewandte Chemie","topic":"Fluorine in Organic Chemistry","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Janssen Research and Development; National Institute of General Medical Sciences; Japan Society for the Promotion of Science; Merck Sharp and Dohme; Ministerio de Economía y Competitividad; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Daiichi-Sankyo; Pfizer; Fonds de recherche du Québec – Nature et technologies; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Aryl; Chemistry; Silylation; Electrophile; Combinatorial chemistry; Halogen; Catalysis; Alkyl; Halide; Aryl radical; Photoredox catalysis; Organic chemistry; Photocatalysis","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001803139,0.0003758406,0.0002165833,0.0001214427,0.0001095194,0.000144093,0.0003012484,0.0002736567,0.0009892696],"category_scores_gemma":[0.0001295589,0.00009153161,0.0001575065,0.00009130112,0.0001512958,0.0001987868,0.0002858742,0.000382459,0.0003221904],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002262895,"about_ca_system_score_gemma":0.0002050256,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005219509,"about_ca_topic_score_gemma":0.001144151,"domain_scores_codex":[0.9998696,0.00001419017,0.000009779949,0.00003191602,0.00003824925,0.00003626135],"domain_scores_gemma":[0.9999654,0.000005224798,0.00001055676,0.000005969952,0.000006632031,0.000006123467],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007283066,0.00001590957,0.0001127887,0.0001666635,0.0000107205,0.0002008966,0.00004970116,0.0001151589,0.9908363,0.0006647986,0.0002150353,0.007539156],"study_design_scores_gemma":[0.00001437665,0.000124747,0.0002513765,0.000005795668,0.000008302275,0.0002528598,0.00001081391,0.0002649293,0.9926111,0.000077608,0.006373865,0.00000426455],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9108993,0.01118239,0.05821531,0.0005747337,0.000243667,0.0001640989,0.0005903451,0.0004818362,0.01764819],"genre_scores_gemma":[0.9844751,0.002671148,0.008317411,0.00007074526,0.00002099933,0.00002492202,0.0001807145,0.0000232539,0.004215661],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009892696,"threshold_uncertainty_score":0.003309369,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08743045432176431,"score_gpt":0.4036400938924435,"score_spread":0.3162096395706792,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}