{"id":"W4250584327","doi":"10.1158/1538-7445.sabcs18-ct190","title":"Abstract CT190: A Phase II basket study of hypomethylating agent oral cc-486 and durvalumab in advanced solid tumors (METADUR)","year":2019,"lang":"en","type":"article","venue":"Clinical Trials","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Durvalumab; Hypomethylating agent; Medicine; Oncology; Internal medicine; Cancer; Chemistry; Nivolumab; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001290121,0.001577271,0.00194254,0.0006176273,0.0003867591,0.001071221,0.001216361,0.001096463,0.005336747],"category_scores_gemma":[0.0007321219,0.0006829811,0.0009865703,0.0005678385,0.0006874806,0.0008751479,0.0004172394,0.00273668,0.001075378],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001336387,"about_ca_system_score_gemma":0.001896289,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001827004,"about_ca_topic_score_gemma":0.005161168,"domain_scores_codex":[0.9996524,0.000136561,0.00001941059,0.00006350129,0.00003935191,0.00008880574],"domain_scores_gemma":[0.9995611,0.00004762591,0.00009421734,0.00004185544,0.00002925134,0.0002259046],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6496966,0.06482214,0.006774124,0.001082751,0.001706219,0.0004215503,0.0003892223,0.002725795,0.1275652,0.0008822008,0.007060627,0.1368735],"study_design_scores_gemma":[0.5536735,0.4221083,0.009044535,0.0000404666,0.0004749055,0.0005898639,0.00008331375,0.001519148,0.007760732,0.000284699,0.004377418,0.00004321601],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902367,0.001853508,0.0006546272,0.0004524705,0.0001056509,0.002992402,0.001563224,0.0001574989,0.001983999],"genre_scores_gemma":[0.9865999,0.001884802,0.002179134,0.0005895115,0.0001188281,0.00251886,0.0027382,0.00004723043,0.003323581],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005336747,"threshold_uncertainty_score":0.01785326,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1351166766805313,"score_gpt":0.4764007058495135,"score_spread":0.3412840291689823,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}