{"id":"W4250584327","doi":"10.1158/1538-7445.sabcs18-ct190","title":"Abstract CT190: A Phase II basket study of hypomethylating agent oral cc-486 and durvalumab in advanced solid tumors (METADUR)","year":2019,"lang":"en","type":"article","venue":"Clinical Trials","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Durvalumab; Hypomethylating agent; Medicine; Oncology; Internal medicine; Cancer; Chemistry; Nivolumab; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005092733,0.0001821965,0.001019662,0.00006150889,0.00003849744,0.00002097628,0.0001677297,0.0001669677,0.00004146038],"category_scores_gemma":[0.008002156,0.0001641618,0.0002077238,0.0001029507,0.00006607609,0.000005465165,0.0002423874,0.0001753273,0.00000595135],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000135092,"about_ca_system_score_gemma":0.0001242565,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007334044,"about_ca_topic_score_gemma":0.00008847655,"domain_scores_codex":[0.9968452,0.0004585181,0.001783502,0.0005273955,0.0001453562,0.0002399757],"domain_scores_gemma":[0.9976591,0.001071399,0.0006283019,0.0004372791,0.00007237434,0.0001315537],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.006232975,0.02462806,0.09141749,0.0001351721,0.0006001201,0.00004093073,0.0005661118,0.0006344367,0.5815352,0.00004801215,0.0005653734,0.2935961],"study_design_scores_gemma":[0.3830065,0.06828474,0.3574476,0.0004883845,0.0007143535,0.00001560359,0.006266817,0.001043196,0.1517316,0.001954756,0.02655084,0.002495659],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972665,0.0009136545,0.00001224496,0.00003725919,0.0004335408,0.0009882441,0.00006581959,0.000005186334,0.0002774936],"genre_scores_gemma":[0.9985085,0.000512079,0.0004114977,0.0001382466,0.0002434696,0.00002864863,0.00003179384,0.00002265214,0.0001031251],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4298036,"threshold_uncertainty_score":0.9579907,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1351166766805313,"score_gpt":0.4764007058495135,"score_spread":0.3412840291689823,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}