{"id":"W4250591910","doi":"10.1093/annonc/mdw594.008","title":"444PD Patient-reported outcomes (PROs) in ASCEND-5: A randomized, phase 3 study of ceritinib vs chemotherapy (CT) in patients (pts) with advanced anaplastic lymphoma kinase rearranged (ALK+) NSCLC previously treated with CT and crizotinib (CRZ)","year":2016,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Ceritinib; Anaplastic lymphoma kinase; Internal medicine; Oncology; Chemotherapy; Phases of clinical research; ALK inhibitor; Lung cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001880899,0.001847555,0.002385324,0.0004575368,0.0003949839,0.001037021,0.0009718738,0.001440983,0.004951003],"category_scores_gemma":[0.001437983,0.0005052434,0.003212898,0.0004179882,0.001046717,0.001126709,0.0005840576,0.003885227,0.0005963512],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001073513,"about_ca_system_score_gemma":0.000938567,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001050885,"about_ca_topic_score_gemma":0.002639949,"domain_scores_codex":[0.9991478,0.0004760638,0.00004264952,0.0001310498,0.00006187599,0.0001405916],"domain_scores_gemma":[0.9990195,0.0002265009,0.0002915746,0.00006202094,0.00004623802,0.0003541969],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9751354,0.003938009,0.001935825,0.0002616395,0.001188859,0.00002716891,0.00002740182,0.0008295026,0.001691709,0.00008564225,0.0006684602,0.01421044],"study_design_scores_gemma":[0.8537983,0.131331,0.01022303,0.00003079309,0.001556258,0.00006618582,0.0000387839,0.001240352,0.0007569743,0.0001955282,0.0007383717,0.00002447911],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934515,0.002368397,0.0002956048,0.0004276917,0.0002147583,0.0009170362,0.001045018,0.00009112561,0.001188887],"genre_scores_gemma":[0.9944185,0.0008623189,0.0006497849,0.000481257,0.000234567,0.001045909,0.001376041,0.0000156527,0.0009159399],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004951003,"threshold_uncertainty_score":0.01656276,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02154295762533763,"score_gpt":0.3615400152613037,"score_spread":0.3399970576359661,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}