{"id":"W4250599156","doi":"10.1200/jco.2012.30.18_suppl.lba671","title":"Open-label phase III randomized controlled trial comparing taxane-based chemotherapy (Tax) with lapatinib (L) or trastuzumab (T) as first-line therapy for women with HER2+ metastatic breast cancer: Interim analysis (IA) of NCIC CTG MA.31/GSK EGF 108919.","year":2012,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Cancer Treatment and Pharmacology","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University; Juravinski Cancer Centre; Sunnybrook Health Science Centre; BC Cancer Agency; Interior Health; Ottawa Hospital; Hamilton Health Sciences; University of Toronto","funders":"","keywords":"Medicine; Docetaxel; Metastatic breast cancer; Internal medicine; Taxane; Clinical endpoint; Trastuzumab; Lapatinib; Breast cancer; Oncology; Pertuzumab; Interim analysis; Surgery; Chemotherapy; Cancer; Randomized controlled trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00305195,0.002563221,0.00441897,0.0004928361,0.0005704332,0.001599221,0.001383723,0.002453539,0.01165752],"category_scores_gemma":[0.003652367,0.000919065,0.00222174,0.0006099592,0.001624569,0.001705174,0.0006028035,0.004545415,0.002200553],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001344233,"about_ca_system_score_gemma":0.00220954,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001483172,"about_ca_topic_score_gemma":0.004728064,"domain_scores_codex":[0.9988727,0.0006708873,0.00006326614,0.0001673307,0.00006249163,0.0001633652],"domain_scores_gemma":[0.997915,0.000648907,0.0005245611,0.0001866702,0.0001380223,0.0005868903],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9906214,0.003560073,0.0001434323,0.0003701085,0.0006586458,0.00001787108,0.0000199532,0.0001419246,0.0005907293,0.00005711953,0.000740409,0.003078469],"study_design_scores_gemma":[0.9743823,0.02423942,0.0003832986,0.0000193919,0.0002231387,0.0000100189,0.0000095027,0.0001828689,0.00008829975,0.00007926363,0.0003764107,0.000006206566],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9398667,0.009564005,0.002145957,0.002709961,0.002967166,0.02820971,0.00648009,0.0006127493,0.007443675],"genre_scores_gemma":[0.9431913,0.003837636,0.004438473,0.003902166,0.001086508,0.03093264,0.004117265,0.00009594084,0.008398009],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01165752,"threshold_uncertainty_score":0.03899825,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1781133608658888,"score_gpt":0.5349206746260675,"score_spread":0.3568073137601787,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}