{"id":"W4250684972","doi":"10.20941/2309-4435.2016.04.2","title":"Integration of Species and Time Dependent in Vitro Liver S9 Microsomal Data and Allometry for Effective Prediction of Human Clearance of Glycovir, an Anti-Human Immunodeficiency Virus (HIV) Drug","year":2016,"lang":"en","type":"article","venue":"Journal of Applied Biopharmaceutics and Pharmacokinetics","topic":"Hepatitis C virus research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"","keywords":"Human immunodeficiency virus (HIV); In vitro; Microsome; Virology; Antiretroviral drug; Biology; Drug; Human liver; Pharmacology; Computational biology; Antiretroviral therapy; Biochemistry; Viral load","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001006847,0.0001658477,0.00051295,0.0003872337,0.00005527387,0.00001707375,0.0001869612,0.00007958618,0.00002129999],"category_scores_gemma":[0.00004009645,0.0001235099,0.00004223105,0.0001740791,0.0003944425,0.0001689014,0.0001493632,0.0002597324,2.51676e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004038621,"about_ca_system_score_gemma":0.00004535326,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001548104,"about_ca_topic_score_gemma":0.000002866518,"domain_scores_codex":[0.9983712,0.00007154998,0.0007560546,0.0002264976,0.0003854504,0.0001892129],"domain_scores_gemma":[0.9987294,0.0001698637,0.0004998453,0.0001875707,0.0002869743,0.0001263119],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002562536,0.0004006616,0.004128824,0.0004778604,0.0001105358,0.000007774623,0.0005575546,0.000004218911,0.9642105,0.00003773144,0.00004200833,0.02745987],"study_design_scores_gemma":[0.006841657,0.0006905984,0.02960716,0.000225965,0.0002515605,0.00002462382,0.0001082074,0.004152585,0.9574359,0.00004426558,0.000517926,0.00009954604],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964015,0.001561334,0.0003716331,0.0000516328,0.00004740635,0.0006502325,0.0008171618,0.000003682892,0.00009538003],"genre_scores_gemma":[0.9912881,0.007597978,0.0009240606,0.00002489173,0.00008708973,0.000003985775,0.00002870953,0.000020665,0.00002447231],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02736033,"threshold_uncertainty_score":0.5036586,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05078911522395727,"score_gpt":0.3611577908110876,"score_spread":0.3103686755871303,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}