{"id":"W4250684972","doi":"10.20941/2309-4435.2016.04.2","title":"Integration of Species and Time Dependent in Vitro Liver S9 Microsomal Data and Allometry for Effective Prediction of Human Clearance of Glycovir, an Anti-Human Immunodeficiency Virus (HIV) Drug","year":2016,"lang":"en","type":"article","venue":"Journal of Applied Biopharmaceutics and Pharmacokinetics","topic":"Hepatitis C virus research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"","keywords":"Human immunodeficiency virus (HIV); In vitro; Microsome; Virology; Antiretroviral drug; Biology; Drug; Human liver; Pharmacology; Computational biology; Antiretroviral therapy; Biochemistry; Viral load","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005880458,0.0002843818,0.0003544345,0.0003115833,0.0001786165,0.0004180655,0.000160952,0.0003195608,0.0005931521],"category_scores_gemma":[0.001026568,0.0001850552,0.0004446817,0.0002746973,0.0001534301,0.0003697197,0.0001845854,0.0004548377,0.0002865466],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004171189,"about_ca_system_score_gemma":0.0002878686,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002932447,"about_ca_topic_score_gemma":0.003352872,"domain_scores_codex":[0.9997504,0.0001138722,0.00001603767,0.00005967834,0.000043037,0.00001684113],"domain_scores_gemma":[0.9995714,0.0002069432,0.00007178935,0.00006205887,0.00006294208,0.00002493179],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.002310524,0.0002042516,0.0194289,0.00008309679,0.000130894,0.00007340746,0.00008223614,0.01001375,0.9394441,0.0002946723,0.0001361317,0.02779809],"study_design_scores_gemma":[0.00002965595,0.001584673,0.0776116,0.000009805156,0.0001885357,0.000380385,0.00007063673,0.1959167,0.7225339,0.0002871352,0.001337907,0.00004913972],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9727218,0.0006657446,0.02545542,0.00003920051,0.00001819787,0.00003383262,0.0003162994,0.0001172058,0.0006323162],"genre_scores_gemma":[0.9947636,0.0002463587,0.004172797,0.00001934076,0.000006547212,0.0000148226,0.0002740638,0.00002746361,0.0004750496],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002932447,"threshold_uncertainty_score":0.005830765,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05078911522395727,"score_gpt":0.3611577908110876,"score_spread":0.3103686755871303,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}