{"id":"W4250746484","doi":"10.1002/ange.201911372","title":"Nickel‐Catalyzed Domino Heck‐Type Reactions Using Methyl Esters as Cross‐Coupling Electrophiles","year":2019,"lang":"en","type":"article","venue":"Angewandte Chemie","topic":"Catalytic Cross-Coupling Reactions","field":"Chemistry","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada; BASF Corporation","keywords":"Electrophile; Chemistry; Heck reaction; Nucleophile; Domino; Hydride; Catalysis; Coupling reaction; Medicinal chemistry; Bond cleavage; Nickel; Palladium; Combinatorial chemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.000242968,0.00043734,0.000474486,0.0001367078,0.0003634015,0.0003020132,0.0004157221,0.0003540405,0.001805865],"category_scores_gemma":[0.0003105214,0.0004745766,0.0003102948,0.000472098,0.0002031034,0.0004441105,0.0001635513,0.0006401013,0.0008611458],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005778454,"about_ca_system_score_gemma":0.0003031352,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008307074,"about_ca_topic_score_gemma":0.00002302061,"domain_scores_codex":[0.9974647,0.000001058496,0.0005760337,0.0008051869,0.0004191581,0.0007338981],"domain_scores_gemma":[0.9977565,0.0002897147,0.0003204698,0.001153853,0.0002519755,0.0002275075],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001348011,0.00009535866,0.00299336,0.0001515417,0.000168635,0.0000176251,0.0001532656,0.0007992352,0.9952662,0.00004522834,0.0001361224,0.00003865347],"study_design_scores_gemma":[0.001085929,0.00001665109,0.0001428509,0.00012911,0.0001648843,0.0002108401,0.000253571,0.0007090047,0.9918985,0.0001700522,0.004685219,0.0005334245],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938889,0.0005350542,0.00001367444,0.00009278549,0.0005363596,0.000167609,0.00003968878,0.0003429623,0.004383017],"genre_scores_gemma":[0.9896642,0.0001039247,0.0001826157,0.00004824183,0.0004735923,0.00002106748,0.0003231541,0.0001258812,0.009057325],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004674308,"threshold_uncertainty_score":0.9999168,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02381457016658336,"score_gpt":0.3078516716016734,"score_spread":0.2840371014350901,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}