{"id":"W4250791950","doi":"10.3410/f.3449956.12773062","title":"Faculty Opinions recommendation of SirT1 enhances survival of human osteoarthritic chondrocytes by repressing protein tyrosine phosphatase 1B and activating the insulin-like growth factor receptor pathway.","year":2011,"lang":"en","type":"dataset","venue":"Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"","keywords":"Insulin-like growth factor; Cancer research; Receptor tyrosine kinase; Insulin receptor; Protein tyrosine phosphatase; Phosphatase; Growth factor; Internal medicine; Chemistry; Cell biology; Endocrinology; Insulin; Receptor; Medicine; Biology; Insulin resistance; Phosphorylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.0009571307,0.001874486,0.001419012,0.001853206,0.000519759,0.001502014,0.001699112,0.002125486,0.02709996],"category_scores_gemma":[0.004701709,0.000414644,0.001952166,0.002786997,0.0002544308,0.0006485209,0.0008767725,0.001035022,0.02028134],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001241151,"about_ca_system_score_gemma":0.002338049,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02630384,"about_ca_topic_score_gemma":0.07327546,"domain_scores_codex":[0.9992431,0.0001482169,0.00009204281,0.000233029,0.0002012431,0.00008239962],"domain_scores_gemma":[0.9984647,0.0004945622,0.0002467561,0.000239574,0.0003816418,0.000172806],"domain_codex":null,"domain_gemma":"evaluation","domain_candidate":"evaluation","domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006237801,0.00007999827,0.004471549,0.003246787,0.0003515955,0.00006139578,0.00002010331,0.0007014522,0.0007230019,0.0002361635,0.9812031,0.008280945],"study_design_scores_gemma":[0.002282645,0.0001869751,0.05068205,0.001093778,0.001051246,0.0003261765,0.00009896487,0.002326675,0.003069826,0.001273496,0.937492,0.0001161959],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"dataset","genre_gemma":"commentary","genre_scores_codex":[0.0008063277,0.000415054,0.00006650558,0.0001823225,0.00003780101,0.00001429671,0.9976591,0.0001699475,0.0006486364],"genre_scores_gemma":[0.001703866,0.0002490627,0.0003063722,0.0001156275,0.00001180399,0.00004899823,0.9966894,0.00002456485,0.0008500921],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.9990429,"threshold_uncertainty_score":0.09065843,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03194697358465635,"score_gpt":0.3205646108305177,"score_spread":0.2886176372458613,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}