{"id":"W4250940821","doi":"10.1093/jcag/gwz047.212","title":"A213 A NOVEL PH-SENSITIVE OPIOID ANALGESIC THAT IS SELECTIVELY ACTIVATED IN ACIDIC INFLAMMATORY ENVIRONMENTS","year":2020,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Pharmacology; Nociception; DAMGO; Nociceptor; Analgesic; Chemistry; Opioid; Extracellular; In vivo; Patch clamp; Ex vivo; Visceral pain; Neuropathic pain; Medicine; Receptor; Anesthesia; Opioid receptor; Biochemistry; In vitro; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005759928,0.0002276872,0.0002254226,0.000132978,0.0001548717,0.0001662636,0.0002328713,0.0003406857,0.001924292],"category_scores_gemma":[0.00005572331,0.00007866756,0.0002963727,0.0001235395,0.000109763,0.0001636802,0.0001401728,0.0003661003,0.00041344],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001159572,"about_ca_system_score_gemma":0.0001424252,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002559083,"about_ca_topic_score_gemma":0.000375707,"domain_scores_codex":[0.9999527,0.00000519337,0.000003404508,0.000009872377,0.00001384249,0.00001499483],"domain_scores_gemma":[0.9999733,0.00000272796,0.000007259286,0.000001786281,0.000004719177,0.0000101367],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001513699,0.00003568817,0.00007032281,0.00006966059,0.000006246471,0.00009102585,0.000003343705,0.00002561393,0.9975616,0.00008960778,0.00006850133,0.001826927],"study_design_scores_gemma":[0.0001998993,0.00293156,0.0103819,0.00003083217,0.00007690681,0.002191189,0.00003600626,0.002064789,0.9703889,0.0002205083,0.01145605,0.0000213477],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9793993,0.008068697,0.005282555,0.0002525601,0.0001133548,0.0001188617,0.0005046187,0.0001263465,0.006133809],"genre_scores_gemma":[0.9872421,0.003507588,0.004071734,0.0002848746,0.00004141919,0.0001055261,0.000573306,0.00001078041,0.004162698],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001924292,"threshold_uncertainty_score":0.006437421,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01245279459430331,"score_gpt":0.2134880834011135,"score_spread":0.2010352888068102,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}