{"id":"W4251122955","doi":"10.2337/diabetes.55.1.27","title":"Costimulation Blockade of Both Inducible Costimulator and CD40 Ligand Induces Dominant Tolerance to Islet Allografts and Prevents Spontaneous Autoimmune Diabetes in the NOD Mouse","year":2006,"lang":"en","type":"article","venue":"Diabetes","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Nod; NOD mice; Islet; Autoimmune diabetes; Blockade; Immunology; Medicine; CD40; Diabetes mellitus; Biology; Receptor; Endocrinology; Internal medicine; Cytotoxic T cell; Genetics; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002234487,0.0007237996,0.0003346328,0.0003547593,0.000178887,0.0003201566,0.0002683303,0.0002738545,0.001148775],"category_scores_gemma":[0.0001138599,0.000153529,0.0002323877,0.0001559886,0.0002280387,0.0002139357,0.0001888972,0.0008530355,0.0002964818],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002478533,"about_ca_system_score_gemma":0.0003285078,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003780498,"about_ca_topic_score_gemma":0.001026305,"domain_scores_codex":[0.9996578,0.00005278406,0.00004240719,0.00005439929,0.00008638133,0.0001062523],"domain_scores_gemma":[0.9997949,0.00002087497,0.00005859938,0.00002404629,0.00001318792,0.00008832342],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001467313,0.0001343904,0.0002640232,0.00002621828,0.000004268868,0.0000433919,0.00001105672,0.00005450188,0.9983122,0.00008651419,0.00002367936,0.0008930243],"study_design_scores_gemma":[0.00007923578,0.001692386,0.005363427,0.00001541005,0.00002988122,0.0004031645,0.00002308169,0.0008441972,0.9896628,0.00005569098,0.001825523,0.000005080313],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968449,0.0006537134,0.00107596,0.00004773335,0.00002064337,0.00002492884,0.0001393343,0.00005986327,0.001132965],"genre_scores_gemma":[0.9943612,0.0006123104,0.001535665,0.00005132027,0.00002116973,0.00008299501,0.0003555806,0.0000247695,0.002954862],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001148775,"threshold_uncertainty_score":0.003843069,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004399413967372138,"score_gpt":0.2128444204961516,"score_spread":0.2084450065287794,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}