{"id":"W4251136508","doi":"10.21203/rs.3.rs-140983/v1","title":"Gene Regulatory Network Analysis Defines Transcriptome Landscape with Alternative Splicing of Human Umbilical Vein Endothelial Cells during Replicative Senescence","year":2021,"lang":"en","type":"preprint","venue":"Research Square","topic":"Atherosclerosis and Cardiovascular Diseases","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"BC Cancer Agency","keywords":"Biology; Transcriptome; Senescence; Alternative splicing; Cell biology; RNA splicing; Gene; Gene regulatory network; Human umbilical vein endothelial cell; Gene expression; Genetics; Endothelial stem cell; Exon; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001291717,0.0001636356,0.0002434999,0.0006814802,0.0001711962,0.0003184082,0.0001237448,0.0001300763,0.0007770901],"category_scores_gemma":[0.0003175151,0.00009308484,0.0003030606,0.0009122182,0.0001267272,0.0001506016,0.0001641527,0.0001409683,0.0001437698],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002776421,"about_ca_system_score_gemma":0.0002140067,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001269633,"about_ca_topic_score_gemma":0.001225151,"domain_scores_codex":[0.9998753,0.0000200525,0.000005928673,0.00005273375,0.000022988,0.00002297899],"domain_scores_gemma":[0.9998701,0.00004049753,0.00004032049,0.000009814881,0.0000244495,0.00001486439],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001044617,0.0001464064,0.1598931,0.0005896121,0.0003801054,0.0007360802,0.0004851775,0.04098617,0.7295026,0.00360882,0.001656436,0.0609711],"study_design_scores_gemma":[0.00002793012,0.0003001769,0.6042184,0.00004075285,0.0002616547,0.0006182853,0.0003679532,0.3054293,0.0776012,0.006069685,0.005022158,0.00004255469],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9858213,0.0004877491,0.009953544,0.0000443069,0.000007024169,0.00001503859,0.002713542,0.0001349488,0.000822465],"genre_scores_gemma":[0.9900268,0.0002647973,0.004775033,0.0000187337,0.000005687074,0.0000370626,0.004349482,0.0000208285,0.000501629],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001269633,"threshold_uncertainty_score":0.002599657,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02798313220848794,"score_gpt":0.3044522878134234,"score_spread":0.2764691556049355,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}