{"id":"W4251177956","doi":"10.1128/.20.17.6550-6567.2000","title":"In-Depth Mutational Analysis of the Promyelocytic Leukemia Zinc Finger BTB/POZ Domain Reveals Motifs and Residues Required for Biological and Transcriptional Functions","year":2000,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"Retinoids in leukemia and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research","funders":"","keywords":"Transcription factor; Biology; Zinc finger; Mutant; Transcription (linguistics); Cell biology; Dimer; Point mutation; Molecular biology; Genetics; Chemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008323236,0.0002909664,0.0001120453,0.0001317361,0.0001296551,0.0001022848,0.0001400848,0.0001759906,0.0007764506],"category_scores_gemma":[0.000147729,0.00006029197,0.00016513,0.0001057254,0.0001292656,0.00008556685,0.0001244402,0.00022802,0.000257819],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001668288,"about_ca_system_score_gemma":0.000116365,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005698671,"about_ca_topic_score_gemma":0.0005852886,"domain_scores_codex":[0.9999516,0.00000963301,0.000004435317,0.000007690441,0.00001712336,0.000009447142],"domain_scores_gemma":[0.9999505,0.0000130688,0.00001234152,0.000005217261,0.000006955456,0.00001187699],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001413327,0.00004565537,0.002428127,0.00004212007,0.000011781,0.0003959336,0.00002877332,0.0003722935,0.9938481,0.0001200023,0.00004365358,0.002522188],"study_design_scores_gemma":[0.00008781436,0.0005283343,0.08233509,0.00003149197,0.0001284392,0.005836202,0.0001540786,0.007247364,0.896189,0.0003751158,0.007067859,0.00001914772],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974877,0.0002378517,0.001514867,0.00003480917,0.000003685662,0.00001739935,0.0002076931,0.00001477778,0.000481175],"genre_scores_gemma":[0.9983272,0.0001371474,0.0009152928,0.00001685577,0.000002660959,0.000005531067,0.0003101219,0.00000531952,0.0002799076],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007764506,"threshold_uncertainty_score":0.002597451,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01044064395447021,"score_gpt":0.2418794431135888,"score_spread":0.2314387991591186,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}