{"id":"W4251235346","doi":"10.32920/ryerson.14668524.v1","title":"Mechanisms Of Organelle Identity and Adaptation In Immune Cells","year":2021,"lang":"en","type":"preprint","venue":"","topic":"Calcium signaling and nucleotide metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Metropolitan University","funders":"","keywords":"Cell biology; Phosphatidylinositol; Biology; Phagocytosis; Organelle; Immune system; Endosome; Phagocyte; Phagosome; Endocytosis; Antigen presentation; Acquired immune system; Lysosome; Intracellular; Kinase; Cell; Immunology; T cell; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002547452,0.0001923052,0.0002718507,0.0003372316,0.0002485581,0.0006777362,0.0003744017,0.0006496883,0.0005057457],"category_scores_gemma":[0.0001917528,0.0001462535,0.0003697732,0.0001525525,0.0005567054,0.0008691885,0.0006263867,0.0005634162,0.0003137307],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005238029,"about_ca_system_score_gemma":0.0001582858,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001964473,"about_ca_topic_score_gemma":0.0001609916,"domain_scores_codex":[0.9997478,0.00003867073,0.0000176602,0.0000784146,0.00005156837,0.00006588384],"domain_scores_gemma":[0.9998466,0.00001730395,0.00005056934,0.0000261234,0.00002356746,0.00003579466],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.00009096708,0.00001059545,0.0005728395,0.00007231862,0.000005689596,0.000138983,0.00005958858,0.0001849823,0.993968,0.001535937,0.00004982526,0.003310161],"study_design_scores_gemma":[0.00001929486,0.000240743,0.02353597,0.0000219398,0.00001910068,0.0009716683,0.0002083256,0.002448785,0.9626788,0.001868041,0.007957335,0.00003012238],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.961829,0.01219092,0.02225568,0.0003569562,0.00005961222,0.00006735935,0.0002685621,0.0002158912,0.002755949],"genre_scores_gemma":[0.9914675,0.001976758,0.004719964,0.0001242943,0.0000182157,0.00004551952,0.0001600314,0.00001629219,0.001471402],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006777362,"threshold_uncertainty_score":0.003800511,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01728881704410459,"score_gpt":0.2482294521924523,"score_spread":0.2309406351483477,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}