{"id":"W4251289005","doi":"10.1089/hgt.2008.009","title":"Protein trans-splicing as a means for viral vector-mediated in vivo gene therapy","year":2008,"lang":"en","type":"article","venue":"Human Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Canadian Institutes of Health Research; National Institutes of Health; Muscular Dystrophy Association","keywords":"Genetic enhancement; Vector (molecular biology); Viral vector; In vivo; RNA splicing; Gene; Biology; Virology; Vectors in gene therapy; Computational biology; Trans-splicing; Genetics; Cancer research; RNA; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007114531,0.0004666888,0.0003091688,0.0003917715,0.000188522,0.0005098505,0.0003628804,0.0004740671,0.001139013],"category_scores_gemma":[0.0002946808,0.0002582954,0.0003341241,0.0002193419,0.0005859706,0.0003595779,0.0004103231,0.001189386,0.0006904803],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003316202,"about_ca_system_score_gemma":0.0002575603,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001830183,"about_ca_topic_score_gemma":0.0002373665,"domain_scores_codex":[0.9994625,0.0001649067,0.00004064551,0.00008085375,0.0002133869,0.00003767633],"domain_scores_gemma":[0.9998312,0.00004955057,0.00003758416,0.00004036147,0.0000219523,0.00001936657],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004150654,0.00004338567,0.0001070819,0.00006312619,0.00000781496,0.00007187853,0.00004112384,0.0002202722,0.9887307,0.003118632,0.0001282793,0.00742624],"study_design_scores_gemma":[0.00001469207,0.0002187311,0.0002326695,0.000007194425,0.00001441138,0.0005713632,0.00001160987,0.001186822,0.9875969,0.0003470696,0.00979288,0.000005685845],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5366512,0.01074276,0.436635,0.0009294611,0.0006195662,0.0005165855,0.0003530953,0.001049623,0.01250274],"genre_scores_gemma":[0.8355172,0.007056496,0.1448961,0.0002027736,0.0000892382,0.0002940095,0.0005543968,0.0002243823,0.01116547],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001139013,"threshold_uncertainty_score":0.003810406,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03911417752101874,"score_gpt":0.3109362192394155,"score_spread":0.2718220417183967,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}