{"id":"W4251289005","doi":"10.1089/hgt.2008.009","title":"Protein trans-splicing as a means for viral vector-mediated in vivo gene therapy","year":2008,"lang":"en","type":"article","venue":"Human Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Canadian Institutes of Health Research; National Institutes of Health; Muscular Dystrophy Association","keywords":"Genetic enhancement; Vector (molecular biology); Viral vector; In vivo; RNA splicing; Gene; Biology; Virology; Vectors in gene therapy; Computational biology; Trans-splicing; Genetics; Cancer research; RNA; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005150404,0.0004246128,0.0004017733,0.0001928841,0.0003361338,0.00003259222,0.0005550836,0.000288593,0.0002726368],"category_scores_gemma":[0.0000179695,0.0004042769,0.0002622447,0.0002341441,0.0001949836,0.00001071708,0.00003216247,0.0002167354,0.00001756467],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000645585,"about_ca_system_score_gemma":0.0002554884,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001362597,"about_ca_topic_score_gemma":0.0003644052,"domain_scores_codex":[0.9973897,0.0002428241,0.0004543354,0.0007591163,0.0003622879,0.0007917202],"domain_scores_gemma":[0.9988331,0.00002435002,0.0001080098,0.0007317351,0.0001374867,0.0001652738],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006103429,0.0003200197,0.0002480659,0.00001106809,0.0001469182,0.00002372574,0.0007122931,0.00007600229,0.9897136,0.00002100323,0.0002767277,0.002347119],"study_design_scores_gemma":[0.007009001,0.007608444,0.0005937453,0.00001305903,0.000003062151,0.00002532376,0.00002752597,0.00006540422,0.9727487,0.0002102319,0.01122595,0.0004695648],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927764,0.004053645,0.0003868395,0.0002035152,0.00005842484,0.00215804,0.00006128787,0.0000583784,0.0002434648],"genre_scores_gemma":[0.9923982,0.003318669,0.0004185029,0.0008588033,0.0005402066,0.0008514785,0.0002276516,0.0001565094,0.001229972],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01696494,"threshold_uncertainty_score":0.9998409,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03911417752101874,"score_gpt":0.3109362192394155,"score_spread":0.2718220417183967,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}