{"id":"W4251335645","doi":"10.32920/ryerson.14648496","title":"A Retinal Biophysical Biomarker for Amyotrophic Lateral Sclerosis (ALS)","year":2021,"lang":"en","type":"preprint","venue":"","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Metropolitan University","funders":"","keywords":"Retina; Retinal; Amyotrophic lateral sclerosis; Nerve fiber layer; Ganglion cell layer; Optical coherence tomography; Medicine; Pathology; Optic nerve; Fundus (uterus); Ophthalmology; Anatomy; Neuroscience; Biology; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005642075,0.0003829802,0.0002678457,0.00123291,0.0002600094,0.0006142843,0.0001523378,0.0005958836,0.001201954],"category_scores_gemma":[0.0005785076,0.0001290717,0.0001733761,0.0003735007,0.0002664405,0.0002352935,0.0003580584,0.0003218579,0.0003933552],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001785311,"about_ca_system_score_gemma":0.0001198445,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004092147,"about_ca_topic_score_gemma":0.0004583241,"domain_scores_codex":[0.9997813,0.00005298709,0.0000260427,0.00005453452,0.00006151994,0.00002361625],"domain_scores_gemma":[0.9997889,0.00004195023,0.00007772051,0.00001529872,0.00004544097,0.00003066856],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0008231182,0.0001473796,0.2198952,0.000223007,0.0001543452,0.002273194,0.0003538429,0.0002743234,0.7413303,0.0002321703,0.0005340397,0.03375897],"study_design_scores_gemma":[0.00003262628,0.001279527,0.8434953,0.000076071,0.0001758521,0.01392245,0.0005883474,0.00152511,0.1351918,0.000498954,0.003184919,0.00002896762],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903929,0.003161243,0.00356607,0.0001603869,0.00002643893,0.00003214442,0.0001923269,0.000147215,0.002321254],"genre_scores_gemma":[0.994168,0.0007070255,0.003713779,0.00006642852,0.00001684677,0.00001895952,0.000172078,0.000008148705,0.00112874],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00123291,"threshold_uncertainty_score":0.004020929,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1048038324507035,"score_gpt":0.3463501959659509,"score_spread":0.2415463635152474,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}