{"id":"W4251454374","doi":"10.1093/neuonc/nou239.21","title":"BI-21 * BRAF MUTATION AND CDKN2A DELETIONS DEFINE A CLINICALLY DISTINCT SUBGROUP OF CHILDHOOD SECONDARY HIGH GRADE GLIOMA","year":2014,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children","funders":"","keywords":"ATRX; CDKN2A; Glioma; Biology; IDH1; Cancer research; Oncology; Mutation; Somatic cell; Medicine; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001232209,0.000239157,0.0002272859,0.0004895878,0.0003899926,0.0003328844,0.0002555992,0.0002380503,0.0009516589],"category_scores_gemma":[0.0005932454,0.0001398994,0.0001446908,0.000507653,0.0004244341,0.0001391652,0.0003563678,0.0001820516,0.000195059],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006010646,"about_ca_system_score_gemma":0.000741111,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01728659,"about_ca_topic_score_gemma":0.04461989,"domain_scores_codex":[0.9998147,0.00001713817,0.00001508962,0.00005291558,0.00004631902,0.00005374925],"domain_scores_gemma":[0.999626,0.00003342112,0.0001611511,0.00003321105,0.00004644349,0.00009967005],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001057016,0.00001305107,0.9930539,0.000007706877,0.00001390804,0.0009385009,0.0001232303,0.00004212693,0.004165886,0.00001954728,0.00005092437,0.001465488],"study_design_scores_gemma":[0.000003717372,0.00008400337,0.9956213,0.000001097521,0.000007972929,0.003520402,0.0001575787,0.00009294699,0.000353858,0.00001834562,0.00013735,0.000001423784],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9997285,0.00002058966,0.00002836223,0.000003601691,3.234275e-7,0.000003048297,0.0000478268,0.000002480241,0.0001652529],"genre_scores_gemma":[0.999724,0.0000167407,0.00004141008,0.000003685272,8.541725e-7,0.000002905479,0.0001507485,0.000001487989,0.00005828885],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01728659,"threshold_uncertainty_score":0.03437197,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01455826477408739,"score_gpt":0.2870590009820569,"score_spread":0.2725007362079695,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}