{"id":"W4251498743","doi":"10.32920/ryerson.14654061","title":"Mitogenic and Metabolic signals regulate mTOR complex 1 function to control GSK3β nuclear program","year":2021,"lang":"en","type":"preprint","venue":"","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Metropolitan University","funders":"","keywords":"Cell biology; PI3K/AKT/mTOR pathway; Signal transduction; Biology; mTORC1; Clathrin; Protein kinase B; Scaffold protein; Signal transducing adaptor protein; Receptor; Biochemistry; Endocytosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001506256,0.0004390657,0.0002418814,0.0004139075,0.0003357628,0.0006300099,0.0002240672,0.0002348022,0.002279124],"category_scores_gemma":[0.0002194169,0.000240875,0.0004635707,0.0002093014,0.0003444131,0.0003574668,0.0003973608,0.0006329875,0.0007690049],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005604714,"about_ca_system_score_gemma":0.000457706,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008052315,"about_ca_topic_score_gemma":0.001608027,"domain_scores_codex":[0.9998376,0.00001796036,0.00001199836,0.000043339,0.00003164888,0.00005727473],"domain_scores_gemma":[0.9999145,0.000005287589,0.00003372685,0.000005755377,0.00001669871,0.0000240522],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009496077,0.00006437604,0.003057996,0.0003951825,0.0000532611,0.0002942408,0.0001320361,0.0005584982,0.9793528,0.002579619,0.001593096,0.01096926],"study_design_scores_gemma":[0.0001890179,0.0004531071,0.06900585,0.0001351574,0.0001428514,0.0008398261,0.0002920681,0.00563384,0.8873653,0.002182453,0.03370897,0.0000514983],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9426081,0.02428384,0.01174533,0.001438568,0.0004410249,0.00008107605,0.00175771,0.0009012086,0.01674308],"genre_scores_gemma":[0.9898286,0.003807549,0.002078044,0.0001993115,0.00005598219,0.0000571061,0.0007328022,0.00007923001,0.003161543],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002279124,"threshold_uncertainty_score":0.007624447,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01455186984043649,"score_gpt":0.239801607794156,"score_spread":0.2252497379537195,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}