{"id":"W4251689214","doi":"10.12688/mniopenres.12816.2","title":"Generation of human midbrain organoids from induced pluripotent stem cells","year":2021,"lang":"en","type":"article","venue":"MNI Open Research","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital","funders":"Canadian Institutes of Health Research; Parkinson Canada; Fonds de Recherche du Québec - Santé; Québec Consortium for Drug Discovery; Michael J. Fox Foundation for Parkinson's Research","keywords":"Organoid; Induced pluripotent stem cell; Midbrain; Biology; Neuroscience; Stem cell; Human Induced Pluripotent Stem Cells; Cell biology; Neuromelanin; Dopaminergic; Substantia nigra; Dopamine; Embryonic stem cell; Central nervous system; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003741245,0.0003655773,0.0002183486,0.0004866082,0.0003032482,0.0003650511,0.0003606404,0.0003444758,0.005381846],"category_scores_gemma":[0.0001622573,0.0002833607,0.0003403202,0.0002640568,0.0002570155,0.0002066273,0.0004307712,0.0006879685,0.003401109],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002098051,"about_ca_system_score_gemma":0.0003192964,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003708823,"about_ca_topic_score_gemma":0.001011497,"domain_scores_codex":[0.999809,0.00002311078,0.00003535563,0.0000423807,0.00006990602,0.00002016704],"domain_scores_gemma":[0.9998966,0.00002179035,0.00001504782,0.00003017308,0.00002051759,0.00001583935],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005437797,0.00002145748,0.0001437882,0.0001067492,0.000007323342,0.0002095511,0.00009161248,0.0002462381,0.9899043,0.001053724,0.0008759938,0.007284871],"study_design_scores_gemma":[0.00002092118,0.0001184085,0.001401743,0.0000370635,0.00001690369,0.0004269734,0.00003972339,0.0009637064,0.9516379,0.0002290678,0.0450973,0.00001037534],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5046668,0.0072697,0.3729472,0.001138289,0.00116842,0.004402679,0.0330833,0.003394412,0.07192925],"genre_scores_gemma":[0.6432399,0.006754703,0.2655068,0.0004929608,0.00009692458,0.003148353,0.02837432,0.0006792803,0.05170676],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005381846,"threshold_uncertainty_score":0.01800412,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.202271764542916,"score_gpt":0.4006718460257813,"score_spread":0.1984000814828653,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}