{"id":"W4251689214","doi":"10.12688/mniopenres.12816.2","title":"Generation of human midbrain organoids from induced pluripotent stem cells","year":2021,"lang":"en","type":"article","venue":"MNI Open Research","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital","funders":"Canadian Institutes of Health Research; Parkinson Canada; Fonds de Recherche du Québec - Santé; Québec Consortium for Drug Discovery; Michael J. Fox Foundation for Parkinson's Research","keywords":"Organoid; Induced pluripotent stem cell; Midbrain; Biology; Neuroscience; Stem cell; Human Induced Pluripotent Stem Cells; Cell biology; Neuromelanin; Dopaminergic; Substantia nigra; Dopamine; Embryonic stem cell; Central nervous system; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001481437,0.0001625452,0.0002659383,0.0001185791,0.0002747358,0.0002357758,0.001150753,0.0002513531,0.0005713509],"category_scores_gemma":[0.0001038263,0.0001625439,0.00008636039,0.0004524955,0.000132926,0.00001351952,0.002196386,0.0003796994,0.0001231579],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006858617,"about_ca_system_score_gemma":0.0005779882,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001089247,"about_ca_topic_score_gemma":0.0006729651,"domain_scores_codex":[0.9962957,0.001044263,0.0003874555,0.00079095,0.000923088,0.0005585495],"domain_scores_gemma":[0.9977011,0.00005545265,0.00007093495,0.001080445,0.0008904156,0.0002016239],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000542005,0.0002087193,0.0009153987,0.0000287963,0.00007773536,0.00004883746,0.00009753658,0.000007873004,0.9877232,0.0001030969,0.008816675,0.001917968],"study_design_scores_gemma":[0.000811454,0.0003299651,0.0007593167,0.00002689834,0.000005579654,0.000003323342,0.0004835306,0.0001338249,0.9897543,0.00005948358,0.007463849,0.0001685185],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993045,0.000486105,0.0000830963,0.0004773162,0.0001059695,0.0006441341,0.00008021685,0.000005692429,0.005072521],"genre_scores_gemma":[0.9819735,0.0001202626,0.0004371665,0.00006871329,0.0002948978,0.00006817425,0.0005288118,0.00004389782,0.01646452],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.011392,"threshold_uncertainty_score":0.6628347,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.202271764542916,"score_gpt":0.4006718460257813,"score_spread":0.1984000814828653,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}