{"id":"W4251737244","doi":"10.1002/ange.201610816","title":"Discovery of a PCAF Bromodomain Chemical Probe","year":2016,"lang":"en","type":"article","venue":"Angewandte Chemie","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; Simon Fraser University","funders":"Genentech","keywords":"Bromodomain; PCAF; Chemistry; Subfamily; Biochemistry; Molecular biology; Histone; Cancer research; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008083096,0.000106313,0.0001147595,0.00001874077,0.00001614232,0.000008268875,0.0001401382,0.0001123041,0.00003052785],"category_scores_gemma":[0.0001168263,0.00007205558,0.00009069034,0.0000536311,0.0001105726,0.000008995448,0.00008812773,0.00003086175,0.000009502743],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001291581,"about_ca_system_score_gemma":0.0000445105,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000472127,"about_ca_topic_score_gemma":0.000001851895,"domain_scores_codex":[0.9993315,0.00001251869,0.0001653966,0.0002255744,0.0001089391,0.0001560683],"domain_scores_gemma":[0.9995509,0.000009884567,0.00007227511,0.0002768233,0.00004467314,0.00004548095],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005014591,0.00004202025,0.0004728076,0.00001411405,0.00001946811,7.939194e-7,0.000008697218,1.802565e-8,0.9925646,0.0001580605,0.00589735,0.0007718785],"study_design_scores_gemma":[0.0005581567,0.00006123843,0.0001096667,0.00003516013,0.000006613109,0.000006015546,0.000008085254,9.859208e-8,0.9826745,0.0002590317,0.01616173,0.0001196871],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933987,0.000317191,0.0021586,0.0004060242,0.00006483597,0.0001265389,0.00003635142,0.000013807,0.00347792],"genre_scores_gemma":[0.9956234,0.00007965878,0.0006256915,0.0001206307,0.0002053145,0.00002184786,0.00004786081,0.00001523277,0.003260391],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01026438,"threshold_uncertainty_score":0.2938341,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009802210560623324,"score_gpt":0.2277277016073939,"score_spread":0.2179254910467706,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}