{"id":"W4251737244","doi":"10.1002/ange.201610816","title":"Discovery of a PCAF Bromodomain Chemical Probe","year":2016,"lang":"en","type":"article","venue":"Angewandte Chemie","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; Simon Fraser University","funders":"Genentech","keywords":"Bromodomain; PCAF; Chemistry; Subfamily; Biochemistry; Molecular biology; Histone; Cancer research; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002310914,0.000253322,0.0001371673,0.0001617635,0.0002037409,0.0001816092,0.0003873147,0.0003855944,0.002434843],"category_scores_gemma":[0.0001807197,0.0001379845,0.0002080871,0.0001300796,0.0002146713,0.0001419784,0.0002800475,0.0004170509,0.0006294745],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005041382,"about_ca_system_score_gemma":0.0003529796,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008633055,"about_ca_topic_score_gemma":0.0009286322,"domain_scores_codex":[0.9998653,0.00002182856,0.000004087594,0.00003163642,0.00003144188,0.00004569176],"domain_scores_gemma":[0.9999365,0.00001223827,0.00001171986,0.000008090625,0.00001202723,0.00001949401],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000972532,0.00004592873,0.0001021423,0.00009782836,0.000007922128,0.00009775384,0.00003949349,0.0004425364,0.9902923,0.001785784,0.0005307093,0.006460419],"study_design_scores_gemma":[0.00004169589,0.0003504038,0.0003069003,0.000005564709,0.000006242201,0.0001316269,0.000008990887,0.0008224762,0.9876881,0.0001293842,0.01049907,0.000009552748],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9077764,0.004409004,0.05796072,0.001050691,0.0001330925,0.0003974716,0.001445699,0.0006238944,0.02620305],"genre_scores_gemma":[0.9800131,0.00149876,0.01132692,0.0002982024,0.00001741305,0.000110783,0.0005502892,0.00002190687,0.006162715],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002434843,"threshold_uncertainty_score":0.008145392,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009802210560623324,"score_gpt":0.2277277016073939,"score_spread":0.2179254910467706,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}