{"id":"W4251937406","doi":"10.1038/sj.mt.6300264","title":"Human Matrix Metalloproteinase-8 Gene Delivery Increases the Oncolytic Activity of a Replicating Adenovirus","year":2007,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Research Resources; National Cancer Institute; National Institutes of Health; York University","keywords":"Gene delivery; Oncolytic adenovirus; Matrix metalloproteinase; Oncolytic virus; Genetic enhancement; Matrix (chemical analysis); Biology; Matrix metalloproteinase 9; Metalloproteinase; Cancer research; Gene; Virology; Cell biology; Chemistry; Virus; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001417359,0.0002551462,0.0002548879,0.00009504818,0.0002089535,0.00002925902,0.0006224986,0.0001659918,0.00004949022],"category_scores_gemma":[0.00006944891,0.000201875,0.0002585333,0.000285289,0.0002303236,0.000005752344,0.0001555955,0.0002062421,0.00001066809],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004056844,"about_ca_system_score_gemma":0.0001346707,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003330541,"about_ca_topic_score_gemma":0.0001440363,"domain_scores_codex":[0.9979868,0.0002995428,0.000330349,0.0004918383,0.0004352637,0.0004561963],"domain_scores_gemma":[0.9982215,0.00003911134,0.0002133219,0.001239323,0.0001732923,0.000113425],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001711312,0.0002409814,0.0001881353,0.00001046513,0.0002521483,0.00002709701,0.0000305736,0.00006158492,0.9784965,0.00003730522,0.00003810555,0.01890577],"study_design_scores_gemma":[0.001006854,0.002055611,0.001694707,0.000009299143,0.00001986853,0.00002197983,0.00002814817,0.00001925485,0.9932317,0.00008480616,0.001606854,0.0002209425],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903788,0.006617261,0.001812165,0.0001142193,0.00002100214,0.0007197169,0.00001385449,0.00002477779,0.0002981998],"genre_scores_gemma":[0.998264,0.000281323,0.0005123696,0.0004185829,0.0001230807,0.00007076807,0.00002791559,0.00006598741,0.0002360122],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01868483,"threshold_uncertainty_score":0.8232222,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02336445333979741,"score_gpt":0.332739520812213,"score_spread":0.3093750674724156,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}