{"id":"W4251991087","doi":"10.1093/neuonc/nox168.936","title":"STEM-21. CONTEXT-SPECIFIC TUMOR SUPPRESSIVE FUNCTION OF THE CANONICAL Wnt PATHWAY IN PEDIATRIC MEDULLOBLASTOMA HIGHLIGHTS A THERAPEUTIC STRATEGY FOR TREATMENT-REFRACTORY SUBGROUPS","year":2017,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Wnt signaling pathway; Medulloblastoma; Cancer research; Biology; In vivo; SOX2; Beta-catenin; Context (archaeology); Signal transduction; Cell biology; Transcription factor; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001206151,0.0001990908,0.0002112759,0.0002175828,0.0001158398,0.0002512287,0.00013953,0.0001120486,0.001315901],"category_scores_gemma":[0.0000769368,0.00007853204,0.0001646106,0.0001318113,0.0001305683,0.000127629,0.0001442099,0.0003200535,0.0002732711],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002974907,"about_ca_system_score_gemma":0.0002908327,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007233173,"about_ca_topic_score_gemma":0.002320879,"domain_scores_codex":[0.9999545,0.000006685108,0.000004917087,0.000008200605,0.00001516266,0.00001060782],"domain_scores_gemma":[0.9999653,0.000004373966,0.00001137526,0.000004306975,0.000003072042,0.00001157257],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002862283,0.00006957983,0.003014987,0.000102473,0.00001474389,0.0003828754,0.0000620842,0.0004191177,0.9697616,0.0009348379,0.0004068967,0.02454452],"study_design_scores_gemma":[0.00008219838,0.001517921,0.02518992,0.00002911234,0.0001274295,0.003126469,0.0001222211,0.002170028,0.9371697,0.0003496452,0.03010931,0.000006016661],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9874549,0.005294485,0.003493054,0.0002948811,0.00003856521,0.00006436444,0.0004378362,0.0001763492,0.002745438],"genre_scores_gemma":[0.99303,0.00276867,0.001631467,0.00005965567,0.00001679706,0.00004514338,0.0005727922,0.00002145827,0.001854068],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001315901,"threshold_uncertainty_score":0.004402101,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03219366632729257,"score_gpt":0.2797318604996017,"score_spread":0.2475381941723091,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}