{"id":"W4252001370","doi":"10.1002/ange.201606120","title":"9‐Silafluorenyl Dichlorides as Chemically Ligating Coupling Agents and Their Application in Peptide Synthesis","year":2016,"lang":"en","type":"article","venue":"Angewandte Chemie","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre in Green Chemistry and Catalysis","funders":"","keywords":"Chemistry; Peptide bond; Reagent; Peptide; Epimer; Combinatorial chemistry; Amine gas treating; Chemical ligation; Stoichiometry; Peptide synthesis; Carboxylic acid; Organic chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002049552,0.000191758,0.000222146,0.00003292831,0.00005247884,0.00002301077,0.0001654269,0.0001524341,0.00002990049],"category_scores_gemma":[0.000462675,0.0001312546,0.000100288,0.000103542,0.00009129215,0.000007905694,0.0001251898,0.00005902681,0.00001014516],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000303197,"about_ca_system_score_gemma":0.00001992251,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005646266,"about_ca_topic_score_gemma":0.00002860996,"domain_scores_codex":[0.9989257,0.000008386051,0.000251376,0.0004592945,0.00009829801,0.000256897],"domain_scores_gemma":[0.9993579,0.0001177052,0.00009606994,0.0002795561,0.00004183409,0.0001069482],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002528488,0.00003265433,0.0133592,0.0000174446,0.00003977848,8.810115e-7,0.00002534929,0.000001283351,0.9799861,0.000008087153,0.0002321719,0.006271791],"study_design_scores_gemma":[0.0002290091,0.00001269027,0.001138643,0.00009913959,0.0000209465,0.000003857501,0.00006591892,0.00004560049,0.9939083,0.0002171805,0.004052777,0.0002059204],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976741,0.0004869351,0.0002662866,0.0004974753,0.00001057693,0.00008293874,0.00001368506,0.00001698003,0.0009509873],"genre_scores_gemma":[0.998414,0.0007396237,0.0001692127,0.0001524037,0.0001782724,0.000078816,0.00002557955,0.00002486721,0.0002171768],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01392224,"threshold_uncertainty_score":0.5352408,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008955894298669394,"score_gpt":0.2304293876658821,"score_spread":0.2214734933672127,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}