{"id":"W4252012381","doi":"10.1002/ange.201504661","title":"Switchable Lipids: Conformational Change for Fast pH‐Triggered Cytoplasmic Delivery","year":2015,"lang":"en","type":"article","venue":"Angewandte Chemie","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Sulforhodamine B; Liposome; Chemistry; Ethylene glycol; Biophysics; Cytosol; Conformational change; Endosome; Drug delivery; HeLa; Lipid bilayer; Cationic polymerization; PEG ratio; Biochemistry; Membrane; Cell; Organic chemistry; Cytotoxicity; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001921784,0.0003263546,0.0001524268,0.0001486269,0.0001081932,0.0003545337,0.0002144923,0.0003045169,0.0007769676],"category_scores_gemma":[0.0001790758,0.000145648,0.0001590916,0.0001100452,0.0002458327,0.0003532062,0.0003030586,0.0004596793,0.0003285072],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002686782,"about_ca_system_score_gemma":0.0001648962,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002304311,"about_ca_topic_score_gemma":0.0002408913,"domain_scores_codex":[0.9999193,0.00001637859,0.00000702805,0.0000171932,0.00002309874,0.00001702375],"domain_scores_gemma":[0.9999204,0.00001728936,0.00002524243,0.000009680837,0.000009903241,0.00001748979],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003445903,0.000008132103,0.00001999638,0.00002315227,0.000002473957,0.00003550768,0.00001082744,0.00007257326,0.9984338,0.0001501874,0.00002966931,0.001179243],"study_design_scores_gemma":[0.00002092468,0.00007641561,0.00009986825,0.000002100188,0.000005028067,0.00004920394,0.000003351127,0.0004816768,0.9975148,0.0000311008,0.001710374,0.00000521736],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9684169,0.002285664,0.02623336,0.0003306473,0.0000932437,0.0001025575,0.0002073302,0.0003612721,0.001969019],"genre_scores_gemma":[0.9866689,0.001163974,0.01034426,0.0001066996,0.00001757883,0.00006777828,0.0001008677,0.00006220872,0.001467799],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007769676,"threshold_uncertainty_score":0.002599239,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05095385853748773,"score_gpt":0.2673369422173183,"score_spread":0.2163830836798306,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}