{"id":"W4252013744","doi":"10.26434/chemrxiv-2021-4lgcl","title":"Molecular prosthetics for long-term functional imaging with fluorescent reporters","year":2021,"lang":"en","type":"preprint","venue":"ChemRxiv","topic":"Neuroscience and Neural Engineering","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health","keywords":"Fluorescence; Fluorescent protein; Fluorescence-lifetime imaging microscopy; Biophysics; Neuroscience; Nanotechnology; Chemistry; Biology; Materials science; Green fluorescent protein; Optics; Physics; Biochemistry; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001008673,0.0003473411,0.0002778491,0.0001002862,0.0001266336,0.000277439,0.0003406552,0.00008427413,0.00001295643],"category_scores_gemma":[0.0002132178,0.0003123636,0.0001893393,0.0002027983,0.000158823,0.0001367588,0.0003401218,0.0004597345,0.000002770289],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000070557,"about_ca_system_score_gemma":0.0001831083,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":8.121759e-7,"about_ca_topic_score_gemma":3.531835e-7,"domain_scores_codex":[0.9976045,0.00002091341,0.0002989917,0.001168661,0.0004566092,0.0004503209],"domain_scores_gemma":[0.9988803,0.00005559009,0.0001896198,0.0006474504,0.00008584429,0.0001411541],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002709238,0.00006375367,0.001660724,0.0002546006,0.000005128115,0.0009277488,0.00003827367,0.00190217,0.9944535,0.0000696151,0.00003907075,0.0005582614],"study_design_scores_gemma":[0.0002647898,0.0000312203,0.002331577,0.0002309067,0.00003460684,0.0003733996,0.000007312222,0.003990873,0.9922459,0.0000348335,0.00007690398,0.0003776489],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9818586,0.00009193227,0.01528885,0.0005077519,0.001247461,0.0006997086,0.000003834701,0.0001788269,0.0001230167],"genre_scores_gemma":[0.9982336,0.00003744297,0.0003858265,0.0007771285,0.0001107311,0.0002096476,0.00002575242,0.00007268321,0.0001472351],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01637493,"threshold_uncertainty_score":0.9999328,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03358663097502729,"score_gpt":0.258157292185394,"score_spread":0.2245706612103667,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}