{"id":"W4252116227","doi":"10.1136/annrheumdis-2016-eular.3256","title":"FRI0447 Long-Term (156-Week) Efficacy and Safety Profile of Apremilast, An Oral Phosphodiesterase 4 Inhibitor, in Patients with Psoriatic Arthritis: Results from A Phase III, Randomized, Controlled Trial and Open-Label Extension (Palace 1)","year":2016,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Pharmaceutical studies and practices","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto Western Hospital","funders":"","keywords":"Medicine; Apremilast; Psoriatic arthritis; Randomized controlled trial; Placebo; Internal medicine; Rheumatology; Surgery; Arthritis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002110072,0.001264741,0.00291158,0.000556196,0.0004362919,0.001098411,0.001118896,0.001784588,0.008073027],"category_scores_gemma":[0.001583302,0.0007665016,0.00280502,0.000480365,0.001107996,0.001531651,0.0003377831,0.004087955,0.00157521],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005053527,"about_ca_system_score_gemma":0.0009397084,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006448848,"about_ca_topic_score_gemma":0.001439685,"domain_scores_codex":[0.9992343,0.0003442822,0.00006577481,0.0001302656,0.00009313247,0.0001322743],"domain_scores_gemma":[0.9990147,0.0002632765,0.0002448486,0.0001132222,0.00005909309,0.0003047821],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9047632,0.01563691,0.001175665,0.001044742,0.001823055,0.0001095936,0.00008262367,0.0007029476,0.0164015,0.0001094077,0.001672921,0.05647746],"study_design_scores_gemma":[0.7845348,0.2023643,0.008051528,0.00004050723,0.0009253378,0.0001755531,0.00003498225,0.0005050477,0.002198094,0.00008189345,0.001047378,0.00004070725],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9833787,0.009226836,0.0007957041,0.0006598764,0.0003246686,0.000895826,0.002428671,0.0003119191,0.001977785],"genre_scores_gemma":[0.9851251,0.004130386,0.001853169,0.001177288,0.0005358036,0.001142469,0.002817244,0.00005814626,0.003160355],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008073027,"threshold_uncertainty_score":0.02700698,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0621483049187988,"score_gpt":0.3675748343249025,"score_spread":0.3054265294061037,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}