{"id":"W4252116227","doi":"10.1136/annrheumdis-2016-eular.3256","title":"FRI0447 Long-Term (156-Week) Efficacy and Safety Profile of Apremilast, An Oral Phosphodiesterase 4 Inhibitor, in Patients with Psoriatic Arthritis: Results from A Phase III, Randomized, Controlled Trial and Open-Label Extension (Palace 1)","year":2016,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Pharmaceutical studies and practices","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto Western Hospital","funders":"","keywords":"Medicine; Apremilast; Psoriatic arthritis; Randomized controlled trial; Placebo; Internal medicine; Rheumatology; Surgery; Arthritis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001024471,0.0002635451,0.002004714,0.00005384858,0.0001033989,0.00004227102,0.0001679488,0.00005424516,0.00006019663],"category_scores_gemma":[0.004967803,0.0001216139,0.00009741167,0.0001154135,0.0004136667,0.0004107755,0.000232497,0.00009686162,8.994411e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001225323,"about_ca_system_score_gemma":0.00008925892,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002091682,"about_ca_topic_score_gemma":0.00003233704,"domain_scores_codex":[0.9971117,0.0006487495,0.00119598,0.0003696538,0.0004266355,0.0002472223],"domain_scores_gemma":[0.9946202,0.003628265,0.0008826586,0.000408059,0.0002125189,0.0002483171],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9008158,0.007030174,0.002160082,0.0001190183,0.0005923278,0.000005757373,0.000321828,5.110305e-7,0.00002970597,0.00001011864,0.000260959,0.08865375],"study_design_scores_gemma":[0.9571754,0.002536354,0.0331249,0.005553938,0.0008168155,0.000001101916,0.00006529968,0.0001711918,0.0002385345,0.0001395477,0.0000140835,0.0001628724],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9843519,0.006883014,0.00001242288,0.001326318,0.0001349808,0.006787674,0.0004481667,0.000012324,0.00004324179],"genre_scores_gemma":[0.9939839,0.005420281,0.0001059744,0.0001926803,0.00003259546,0.0001671585,0.00004033393,0.00001742795,0.00003961908],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08849088,"threshold_uncertainty_score":0.5947283,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0621483049187988,"score_gpt":0.3675748343249025,"score_spread":0.3054265294061037,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}