{"id":"W4252141192","doi":"10.26434/chemrxiv.9956213","title":"Total Synthesis of (S,S)-Tetramethylmagnolamine via Aerobic Desymmetrization","year":2019,"lang":"en","type":"preprint","venue":"ChemRxiv","topic":"Biological Activity of Diterpenoids and Biflavonoids","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Fonds de recherche du Québec – Nature et technologies; Natural Sciences and Engineering Research Council of Canada; McGill University","keywords":"Desymmetrization; Chemistry; Oxygen atom; Catalysis; Phenols; Molecular oxygen; Oxygen; Stereochemistry; Combinatorial chemistry; Molecule; Organic chemistry; Enantioselective synthesis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000132009,0.0002917476,0.0001700855,0.0001130812,0.0001275532,0.0001530864,0.0003047132,0.0001992473,0.002419727],"category_scores_gemma":[0.00008422697,0.0001015181,0.0001970676,0.0001340828,0.00012764,0.0002439735,0.0002674231,0.0003381573,0.001075606],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003557727,"about_ca_system_score_gemma":0.0003077689,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005662412,"about_ca_topic_score_gemma":0.0009517578,"domain_scores_codex":[0.9999239,0.000008824342,0.000007027111,0.0000224901,0.00001887337,0.00001882004],"domain_scores_gemma":[0.9999546,0.000003761661,0.00001089644,0.00001076535,0.000008536501,0.00001141225],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000613361,0.00002276064,0.00007762103,0.0001037614,0.00001137589,0.0001326599,0.00006708021,0.0002814989,0.9877613,0.001536475,0.0002848423,0.009659297],"study_design_scores_gemma":[0.00002047352,0.0003345702,0.0003899887,0.000006025089,0.00001201894,0.0002580692,0.00001583976,0.0006224709,0.9787586,0.0002357453,0.01933562,0.00001071177],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9009913,0.003050711,0.06676765,0.0004787965,0.0002156368,0.0002060716,0.00171622,0.0007090548,0.02586458],"genre_scores_gemma":[0.9710706,0.001479648,0.01969513,0.00006799559,0.0000223988,0.00007629379,0.0007767777,0.00007834422,0.006732865],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002419727,"threshold_uncertainty_score":0.008094847,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01130297204689421,"score_gpt":0.2334396229838906,"score_spread":0.2221366509369964,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}