{"id":"W4252179901","doi":"10.1042/0264-6021:3460313","title":"Inhibition of atrial natriuretic peptide (ANP) C receptor expression by antisense oligodeoxynucleotides in A10 vascular smooth-muscle cells is associated with attenuation of ANP-C-receptor-mediated inhibition of adenylyl cyclase","year":2000,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Heart Failure Treatment and Management","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Medical Research Council; Genentech; Medical Research Council Canada","keywords":"Adenylyl cyclase; NPR2; Internal medicine; Atrial natriuretic peptide; Receptor; NPR1; Endocrinology; Chemistry; ADCY9; Biology; Natriuretic peptide; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002491784,0.0005115967,0.0003268232,0.0001443827,0.0001648606,0.000306138,0.0002526052,0.0003494726,0.001222306],"category_scores_gemma":[0.0001413921,0.000219382,0.0003351964,0.0001217826,0.0002603783,0.0001272863,0.0001389103,0.0008660441,0.0004377094],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002961321,"about_ca_system_score_gemma":0.0003151784,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001520669,"about_ca_topic_score_gemma":0.001870012,"domain_scores_codex":[0.9997242,0.00004722587,0.00003824789,0.00005710789,0.00006654112,0.00006673992],"domain_scores_gemma":[0.999749,0.00006731483,0.00004986753,0.00002249118,0.00003161097,0.00007983328],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003445863,0.00001714649,0.00002064311,0.000009367733,0.000001787422,0.000009203583,0.000006508559,0.00001032699,0.9997597,0.00001703976,0.000006129907,0.0001076784],"study_design_scores_gemma":[0.00002763729,0.0009631641,0.001449537,0.000004454834,0.00001884815,0.00009326217,0.0000297631,0.000653391,0.9954918,0.00001251324,0.001251076,0.00000455972],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964802,0.000582676,0.001612885,0.00007078335,0.00006763619,0.0000338969,0.0001808708,0.00005148042,0.0009196363],"genre_scores_gemma":[0.9888314,0.001089923,0.00510532,0.0001082463,0.00002801282,0.0001123824,0.0006735279,0.00002490391,0.004026198],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001520669,"threshold_uncertainty_score":0.004089057,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00784272085003391,"score_gpt":0.2235526577205018,"score_spread":0.2157099368704679,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}