{"id":"W4252461758","doi":"10.32920/ryerson.14662083.v1","title":"Synthesis Of Molecular Probes For Cystic Fibrosis Research","year":2021,"lang":"en","type":"preprint","venue":"","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Metropolitan University","funders":"","keywords":"Cystic fibrosis transmembrane conductance regulator; Cystic fibrosis; Mutant; Membrane protein; Mutation; Phosphorylation; Cell biology; Chemistry; Chloride channel; Transmembrane protein; Ion channel; Mutant protein; Membrane; Biology; Biochemistry; Gene; Genetics; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006258517,0.0006628894,0.0004232008,0.0006998159,0.0004575113,0.0004145484,0.0005889093,0.001085696,0.02552949],"category_scores_gemma":[0.000699024,0.0004667893,0.0003890436,0.0004866957,0.0003023651,0.0008275223,0.0005397404,0.001996249,0.01164516],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004968565,"about_ca_system_score_gemma":0.0005257733,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002264568,"about_ca_topic_score_gemma":0.0003974152,"domain_scores_codex":[0.9996476,0.00008608603,0.00001528603,0.00007844646,0.0001022167,0.00007033948],"domain_scores_gemma":[0.9998048,0.00004914267,0.00002023037,0.00004431168,0.00003773963,0.00004367885],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002106225,0.0001420087,0.0001247568,0.0009973029,0.00005289092,0.000413049,0.0001443273,0.0007901619,0.8557702,0.04649947,0.01722326,0.07763195],"study_design_scores_gemma":[0.0001236456,0.0005867188,0.0003419862,0.000113318,0.00003218411,0.0004597093,0.00003501741,0.001034853,0.4932898,0.006089114,0.4978583,0.00003544411],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.09480222,0.06540696,0.5353698,0.007307824,0.01040794,0.003150335,0.005505293,0.004964562,0.2730851],"genre_scores_gemma":[0.4092109,0.0416208,0.3157396,0.004394604,0.0008064966,0.004999792,0.007657247,0.0008675816,0.214703],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.02552949,"threshold_uncertainty_score":0.08540457,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0554669415323461,"score_gpt":0.4004947586216521,"score_spread":0.345027817089306,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}