{"id":"W4252473439","doi":"10.22215/etd/2017-11975","title":"Harnessing New Genomics Technologies to Assess Environmental Risk Factors That May Cause Heritable Genetic Disease","year":2017,"lang":"en","type":"dissertation","venue":"","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Health Canada","keywords":"Offspring; Biology; Genetics; Germline mutation; Germline; Mutation; Sperm; Mutagen; Somatic cell; Gene; Carcinogen; Pregnancy","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007967664,0.0004494943,0.0005282288,0.0008431829,0.0001592485,0.0008313123,0.0003194642,0.000618732,0.002199023],"category_scores_gemma":[0.0005787287,0.0002203825,0.0004829448,0.000373912,0.0002906639,0.0005369009,0.000443638,0.001117903,0.0006828523],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000306846,"about_ca_system_score_gemma":0.0003596403,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003750265,"about_ca_topic_score_gemma":0.000820367,"domain_scores_codex":[0.9996368,0.00006111868,0.00001806465,0.0001222642,0.0001289572,0.00003275347],"domain_scores_gemma":[0.9996606,0.0001341284,0.00008972725,0.00004022218,0.00004566202,0.0000297197],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.00005508914,0.00008456653,0.004777167,0.0003065192,0.00009151394,0.0001680439,0.000101418,0.0008500579,0.9309456,0.003374336,0.0006359983,0.05860975],"study_design_scores_gemma":[0.00006309803,0.001350633,0.04601516,0.0002376402,0.0004239801,0.001660016,0.0004719411,0.00822952,0.8700774,0.01270788,0.05864745,0.0001153419],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5218309,0.01690178,0.4287792,0.003739082,0.000509272,0.0004408785,0.004969903,0.001204024,0.02162502],"genre_scores_gemma":[0.7074268,0.02939455,0.2390159,0.002178748,0.0002175529,0.0004860408,0.003238597,0.0002153674,0.0178264],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002199023,"threshold_uncertainty_score":0.007356465,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01868264477715357,"score_gpt":0.2982302839471086,"score_spread":0.279547639169955,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}