{"id":"W4252550553","doi":"10.21203/rs.3.rs-337405/v1","title":"A mouse model of neoadjuvant chemotherapy followed by interval cytoreductive surgery indicates impaired efficacy of perioperative cisplatin","year":2021,"lang":"en","type":"preprint","venue":"Research Square","topic":"Intraperitoneal and Appendiceal Malignancies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto","funders":"","keywords":"Cisplatin; Perioperative; Interval (graph theory); Chemotherapy; Medicine; Cytoreductive surgery; Oncology; Internal medicine; Urology; Surgery; Cancer; Mathematics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001275249,0.0004668467,0.001810583,0.0005366683,0.0001231704,0.0000641325,0.000379573,0.000517546,0.0003082594],"category_scores_gemma":[0.0008227245,0.0003877665,0.0007910065,0.0005076182,0.000889003,0.000102342,0.000643727,0.001574865,0.000005511258],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000281654,"about_ca_system_score_gemma":0.002182943,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009912783,"about_ca_topic_score_gemma":0.00001717975,"domain_scores_codex":[0.9953697,0.000487589,0.0009987617,0.0008307247,0.001568124,0.0007451203],"domain_scores_gemma":[0.9963645,0.0006666075,0.0003917387,0.0007396842,0.001535204,0.0003022469],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003555943,0.002305064,0.003240465,0.004277501,0.0009229808,0.0000999551,0.02320072,0.0003337504,0.9564379,0.0001151854,0.002438257,0.003072293],"study_design_scores_gemma":[0.00221166,0.001022489,0.00343486,0.005240518,0.00009437873,0.00001761115,0.008733038,0.005720972,0.9729835,0.00006345031,0.00005178994,0.0004257241],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942054,0.001774614,0.0001225959,0.000938544,0.00009791597,0.001662665,0.0008158285,0.00004899201,0.0003335172],"genre_scores_gemma":[0.9955924,0.0008888184,0.0008177083,0.00004393309,0.0001365362,0.0002045837,0.0008217883,0.00009080508,0.001403437],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01654562,"threshold_uncertainty_score":0.9998574,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06454590971223403,"score_gpt":0.373479440099606,"score_spread":0.3089335303873719,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}