{"id":"W4252639308","doi":"10.1210/en.142.6.2614","title":"Thiol-Reactive Agents Biphasically Regulate Inositol 1,4,5-Trisphosphate Binding and Ca2+ Release Activities in Bovine Adrenal Cortex Microsomes","year":2001,"lang":"en","type":"article","venue":"Endocrinology","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Canadian Institutes of Health Research","keywords":"Dithiothreitol; Inositol; Receptor; Thiol; Intracellular; Internal medicine; Endocrinology; Chemistry; Inositol phosphate; Microsome; Adrenal cortex; Western blot; Biochemistry; Biology; In vitro; Enzyme; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007358616,0.0002319439,0.0002598463,0.0001702602,0.0001124131,0.00002882274,0.0001276186,0.0001599118,0.00004820077],"category_scores_gemma":[0.00007101849,0.0002342762,0.00006774402,0.0001490742,0.0001764982,0.00001315124,0.0001619587,0.0001905279,0.000006763932],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003975736,"about_ca_system_score_gemma":0.00006488139,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001176772,"about_ca_topic_score_gemma":0.0001103186,"domain_scores_codex":[0.9985288,0.0001081137,0.0002718969,0.0004894302,0.0001037896,0.0004979208],"domain_scores_gemma":[0.9994599,0.00002721022,0.000127518,0.0002384387,0.0000379295,0.0001090199],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005788392,0.0001014986,0.03062867,0.00001647085,0.00006881635,0.00032872,0.00009058153,0.00002153783,0.9582558,0.0002692284,0.0002999398,0.009339882],"study_design_scores_gemma":[0.002573159,0.0003490664,0.07015392,0.00005562281,0.00002871012,0.0005371583,0.0001711402,0.0001547512,0.8952436,0.0001949748,0.03010452,0.0004333521],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968368,0.001675586,0.000144382,0.0006276555,0.0001176179,0.0002572855,0.0000275827,0.00002948907,0.0002836057],"genre_scores_gemma":[0.9973943,0.000926907,0.0002862691,0.0004044179,0.0001149457,0.00003765091,0.0001169003,0.00002611581,0.0006925093],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06301218,"threshold_uncertainty_score":0.9553505,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01026977057770495,"score_gpt":0.2557221725918658,"score_spread":0.2454524020141609,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}