{"id":"W4252639308","doi":"10.1210/en.142.6.2614","title":"Thiol-Reactive Agents Biphasically Regulate Inositol 1,4,5-Trisphosphate Binding and Ca2+ Release Activities in Bovine Adrenal Cortex Microsomes","year":2001,"lang":"en","type":"article","venue":"Endocrinology","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Canadian Institutes of Health Research","keywords":"Dithiothreitol; Inositol; Receptor; Thiol; Intracellular; Internal medicine; Endocrinology; Chemistry; Inositol phosphate; Microsome; Adrenal cortex; Western blot; Biochemistry; Biology; In vitro; Enzyme; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001363163,0.0002705083,0.0002212149,0.0001413689,0.00009337733,0.0001864041,0.0001285856,0.0001414662,0.000677201],"category_scores_gemma":[0.0001765099,0.0001225041,0.0001636749,0.000112429,0.0001864402,0.0001595155,0.0001116317,0.0002453307,0.000218065],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002973299,"about_ca_system_score_gemma":0.0001429813,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001187085,"about_ca_topic_score_gemma":0.002038477,"domain_scores_codex":[0.999893,0.00001736271,0.000007952162,0.00002367764,0.00002892804,0.00002903974],"domain_scores_gemma":[0.9998949,0.00002301515,0.00002884614,0.0000146406,0.00001480038,0.00002383594],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000105424,0.00000462579,0.00006442385,0.000009542102,0.000001611291,0.00001520276,0.000008377413,0.00001013704,0.9994763,0.00001494257,0.000007891436,0.0002815239],"study_design_scores_gemma":[0.00001195737,0.000152806,0.006173838,0.000001828458,0.00001393538,0.0001160695,0.00002052011,0.0002907668,0.9925401,0.00002634864,0.00064728,0.000004599286],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948769,0.00229287,0.001735409,0.00007453244,0.00001855234,0.00001346589,0.0001940883,0.00007011377,0.0007241296],"genre_scores_gemma":[0.9965281,0.0006981448,0.001006624,0.00003558228,0.000009036559,0.00001408565,0.0003197714,0.00001598404,0.001372653],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001187085,"threshold_uncertainty_score":0.002360344,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01026977057770495,"score_gpt":0.2557221725918658,"score_spread":0.2454524020141609,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}