{"id":"W4252697113","doi":"10.1002/ange.201309464","title":"Polyethylene Glycol Backfilling Mitigates the Negative Impact of the Protein Corona on Nanoparticle Cell Targeting","year":2014,"lang":"en","type":"article","venue":"Angewandte Chemie","topic":"Nanoparticle-Based Drug Delivery","field":"Materials Science","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Polyethylene glycol; PEG ratio; Nanoparticle; Ligand (biochemistry); Biophysics; Linker; Chemistry; Corona (planetary geology); Receptor; Molecule; Small molecule; Nanotechnology; Materials science; Biochemistry; Organic chemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001156654,0.0003717625,0.0002133673,0.0001061583,0.00009905945,0.000294498,0.0002256938,0.0003376978,0.0007413678],"category_scores_gemma":[0.0002023215,0.0001348291,0.0001480471,0.00008125142,0.0002153872,0.0002474751,0.0002031488,0.0002983894,0.0002221605],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001756796,"about_ca_system_score_gemma":0.0002028334,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004906567,"about_ca_topic_score_gemma":0.0003921986,"domain_scores_codex":[0.9999034,0.00001529907,0.000007822173,0.00001967877,0.00002892448,0.00002474636],"domain_scores_gemma":[0.9998831,0.00002879756,0.00003744115,0.00001761135,0.00001641825,0.00001663788],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007066779,0.00001639904,0.00004379602,0.00002087293,0.00000264722,0.00003909579,0.00001266952,0.00009220562,0.9982966,0.00007862801,0.00004022956,0.001286195],"study_design_scores_gemma":[0.000003805767,0.00008508831,0.0001537715,0.000001576363,0.000003782761,0.00004187184,0.000003272327,0.0003766248,0.998492,0.00001234438,0.000824403,0.000001522533],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925333,0.0007225513,0.004934498,0.0001475703,0.00004469595,0.00002455525,0.00007284208,0.000228942,0.001290827],"genre_scores_gemma":[0.995203,0.0003368745,0.002515533,0.00008999187,0.000008486049,0.00001371789,0.00006723317,0.00004127344,0.0017238],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007413678,"threshold_uncertainty_score":0.00248009,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01035519165990772,"score_gpt":0.2288764917996146,"score_spread":0.2185213001397069,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}